Beta-lactamases showed tremendous variation in geographic distribution. Thus, their detection and characterization is important from a clinical-epidemiological, laboratory and infection control point of view. Knowledge of this epidemiology can predict the empiric antimicrobial treatment.
Background: India started Covid-19 vaccination from January 16, 2021 after the approval of two candidate vaccines namely Covishield TM and Covaxin TM .We report antibody responses among healthcare workers following two doses of CovishieldTM vaccination in a tertiary care setting.
Methods: This prospective serosurveillance study was done among healthcare workers of JMMC&RI ,vaccinated during January to March 2021. Blood samples were drawn from 170 participants after their 1st dose and from 156 participants after their 2nd dose of COVID vaccine to measure the specific antibodies against the recombinant S1 subunit of the S protein of SARS CoV 2
Results: The median level of anti SARS CoV-2 Ig G antibody 28 days after the first dose
vaccination is 3.64 S/C (IQR=5.91) and 11.6 S/C (IQR= 5.97) after
14 days of second dose vaccination. Protective levels of anti SARS CoV-2 Ig G antibodies
is developed by 25 participants (14.7%) after 28 days of first dose of vaccination and by
109 participants (69.9%) after 14 days of second dose. 18-44 years age group (p=0.027) and absence of comorbidities (p=0.079) are associated with protective IgG levels.
Conclusions: Rise in specific Ig G is observed after vaccination. Higher antibody response is observed with younger age group and absence of comorbidities, though statistically not significant. The influence of BMI is also not significant.
Kerala state in India was known for its early response to the Covid-19 pandemic by public health mitigation measures through science-based advocacy. The objective of this study was to analyze epidemiological and clinical characteristics of COVID-19 patients admitted to a tertiary care center in central Kerala. This retrospective case series was undertaken by reviewing the medical records and extracting the epidemiological data, clinical symptoms and laboratory findings of consecutive patients admitted between April 1st and September 31, 2020. Clinical and demographic parameters of hospitalized patients were analyzed regarding their association with the severity of disease. The mean age of the patients was 35.8 years with significant male predominance. Shopkeepers represented 15.6% of the patients and healthcare workers represented 12.5%. Primary contact with a known case was documented in 62.5% of the patients. Asymptomatic patients constituted 25% of the patients and the most commonly experienced symptoms were fever, cough, breathlessness and diarrhea. Three patients had atypical presentations in the form of generalized seizures, intussusception and generalized anxiety with suicidal ideation. Neutrophilia and Lymphopenia were the most dominant laboratory finding. The clinical spectrum of COVID-19 in the study population is wider than previously described in literature.
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