Background: Though the blood transfusion is lifesaving, it is never risk free and carries potential risk for transfusion transmitted infections (TTIs).The objective of present study is to assess the prevalence and trend of TTIs among blood donors in the blood bank attached to tertiary level government hospital and its comparison with national data and other studies of different regions. Methods: Retrospective cross-sectional study was done including healthy blood donor of 18-65 years from May 2011 to April 2016. TTIs testing were done with 3 rd generation ELISA for HIV, HBV and HCV and HIV testing was also done with 4th generation ELISA from the year 2014 onwards. Syphilis screening was done either by RPR, TPHA strip test or ELISA and Malaria parasite was tested either by peripheral smear or rapid test. Results: From 40971 donors in study, 550 (1.34%) donors were sero-reactive from which 400 (0.98%) donors were reactive for HBV, 67 (0.16%) were for syphilis, 40 (0.098%) were for HCV, 33 (0.081%) were reactive for HIV and 10 (0.024%) were malaria positive. During the study period four donors showed co infection for HIV and HBV. Most common age group to be sero reactive in the present study is 21-30 years of age (43.09% of total). Conclusions: Prevalence of TTIs in the present study was lower as compare to other studies of the India. The reasons behind this finding may be better pre-donation counseling, better life style, higher proportion of voluntary blood donation (> 99%) and high pre-donation deferral rate (11.17%).
In 1940, the cause of Haemolytic Disease of Foetus & Newborn (HDFN) was linked to the Rh blood group system by Levine and Stetson. Rh was the name given to the system because of the similarity of this antibody to one made from stimulating guinea pigs and rabbits with rhesus monkey cells. This Rh antibody, described by Landsteiner and Wiener, agglutinated 85% of human red ABSTRACT Background: Since it was discovered by Karl Landsteiner, the ABO blood group system is the most important blood group system in Transfusion Medicine. The blood group systems are also very important in population genetic studies, researching population migration patterns as well as resolving certain medico-legal issues, particularly disputed parentage. This study was carried out with an objective to provide data regarding gene frequency and distribution of ABO and Rh blood groups among blood donors in South Gujarat, India. Methods: Data of 40732 blood donors were retrospectively collected and analyzed regarding ABO and Rh blood groups from May-2011 to April-2016 and reported in simple numbers and percentage. Blood group of the blood donors was determined by forward and reverse methods with the help of commercially available standard monoclonal antisera by test tube and column agglutination techniques in required cases. Results: The most common blood group among donors was B (34.43%) followed by O (32.26%), A (24.35%), while the least prevalent blood group was AB (8.94%). Rh positivity among donors was (95.12%). Rests were Rh Negative (4.87%). The estimated gene frequencies were 0.1844 for I A (p), 0.2477 for I B (q) and 0.5679 for I O (r). Conclusions: The most common blood group in donors was B positive and least common was AB negative.
Background: Platelet transfusion plays a key role in therapy for the patients with thrombocytopenia. Superiority of Single donor platelet (SDP) over Random donor platelet (RDP) transfusions is largely assumed, but unproven. Platelet Rich Plasma-Platelet concentrate (PRP-PC) and Apheresis-PC were prepared and their therapeutic efficacy were assessed in thrombocytopenic patients.Methods: This study included 60 transfusion episodes consisting of 30 SDP and 30 RDP (147units of RDP). The post transfusion efficacy of transfused platelets was assessed at 1 hour and 24 hours by corrected count increment (CCI) and percentage recovery (PR). Paired ‘t’-test was used for statistical analysis and a probability of p<0.05 was used to reject null hypothesis.Results: The mean platelet dose of SDP (n=30) and RDP (n=30) was 2.86±1.05 x 1011 and 2.36±0.54 x 1011 respectively. The mean platelet increments of SDP at 1 hour and 24 hours were 38±18.1 x 103/μl and 37.3±20.7x 103/μl. The mean platelet increments of RDP at 1 hour and 24 hours were 28.5±11.4 x 103/μl and 26 ±11.6 x 103/μl. The mean CCI of SDP at 1hour and 24 hours were 21.4 ±7.3 x 103/μl and 20.8±7.4 x 103/μl respectively. The mean CCI of RDP at 1hour and 24 hours were 18.5±6.3x 103/μl and 17.4±7.6 x 103/μl respectively.Conclusions: Post-transfusion increments were significantly higher in patients who received SDP as compared to RDP, but the CCI and PR were comparable in both groups of patients.
Introduction:In newborns with hemolytic disease of fetus and newborn, exchange transfusion is one of the treatments. The main objective of this study was to review and establish the practice of exchange transfusion with reconstituted blood in neonates and to observe fall of bilirubin and also rise in hemoglobin and its comparison with related studies. Material and methods:Total 31 neonates with hemolytic disease of fetus and newborn were included in this study and exchange transfusion was carried out to treat hyperbilirubinemia. Exchange transfusion with O Rh negative cells suspended in AB plasma were done for neonates having Rh hemolytic disease of fetus and newborn and O Rh positive cells suspended in AB plasma were used for exchange transfusion to ABO hemolytic disease of fetus and newborn. The pre and post exchange transfusion blood samples were tested for serum bilirubin and hemoglobin.Result: Out of the 31 cases, 20 were of Rhesus (Rh) hemolytic disease of fetus and newborn, while ABO and other blood groups constituted 08 and 03 hemolytic disease of fetus and newborn cases respectively. The average post-exchange fall in serum indirect bilirubin was (53.47%) and average rise in hemoglobin level was 3.06 gm/dl in all 31 cases. Conclusion:The reconstituted blood is immunologically much safer and better than whole blood for purpose of exchange transfusion in hemolytic disease of fetus and newborn because of its superiority in minimizing transfusion reactions and in achieving all the therapeutic effects of exchange transfusion in better way.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.