Transfusion effect of random donor platelet and single donor platelet in thrombocytopenic patients at tertiary care hospital of South Gujarat

Abstract

Background: Platelet transfusion plays a key role in therapy for the patients with thrombocytopenia. Superiority of Single donor platelet (SDP) over Random donor platelet (RDP) transfusions is largely assumed, but unproven. Platelet Rich Plasma-Platelet concentrate (PRP-PC) and Apheresis-PC were prepared and their therapeutic efficacy were assessed in thrombocytopenic patients.Methods: This study included 60 transfusion episodes consisting of 30 SDP and 30 RDP (147units of RDP). The post transfusion efficacy of transfused platelets was assessed at 1 hour and 24 hours by corrected count increment (CCI) and percentage recovery (PR). Paired ‘t’-test was used for statistical analysis and a probability of p<0.05 was used to reject null hypothesis.Results: The mean platelet dose of SDP (n=30) and RDP (n=30) was 2.86±1.05 x 1011 and 2.36±0.54 x 1011 respectively. The mean platelet increments of SDP at 1 hour and 24 hours were 38±18.1 x 103/μl and 37.3±20.7x 103/μl. The mean platelet increments of RDP at 1 hour and 24 hours were 28.5±11.4 x 103/μl and 26 ±11.6 x 103/μl. The mean CCI of SDP at 1hour and 24 hours were 21.4 ±7.3 x 103/μl and 20.8±7.4 x 103/μl respectively. The mean CCI of RDP at 1hour and 24 hours were 18.5±6.3x 103/μl and 17.4±7.6 x 103/μl respectively.Conclusions: Post-transfusion increments were significantly higher in patients who received SDP as compared to RDP, but the CCI and PR were comparable in both groups of patients.

A comparative study of the transfusion effect of single donor apheresis platelets versus random donor platelets in the management of severe dengue infection in children

“…The main outcomes measured are platelet increment (PI), corrected count increment (CCI), percentage recovery (PR) and duration of hospital stay. The parameters can be calculated using the following formula, [6][7][8] CCI in platelets/µl/m 2…”

Human leukocyte antigen alloimmunization prevention mechanisms in blood transfusion

“…[ 77 ] It contains approximately 7 × 10 10 platelets and increases the platelet count by 5000–10,000/μl in an average-sized adult. [ 78 ]…”

“…SDP is also important for shielding the patients from multiple immunological allogenic exposures. [ 78 ] Besides, SDP prepared with the use of platelet additive solutions would seem to be less likely to provoke allergic transfusion reactions, but convincing evidence of the superiority of SDP is not abundant. [ 82 ] With some types of current apheresis technology, the number of WBCs in a SDP averages at least a log less than the number of WBCs in the equivalent pool of RDP.…”

Comparison of Haemonetics MCS Plus and Baxter CS 3000 Plus for Platelet Apheresis: Experienceat a Tertiary Care Hospital

“…Single Donor Platelets offer several advantages over random donor concentrates including higher platelet count per unit, leukocyte reduction during collection, fewer donor exposures thus reducing the risk of infection and alloimmunization. 3 A number of apheresis equipment are available in the market which differ in their methodology and performance characteristics. In the literature we find various studies comparing the different aspects of platelet apheresis equipment.…”