An anti-varicella-zoster virus compound, a 5-chlorobenzo[b]thiophen derivative (45B5), was characterized. Its 50% effective concentration against the cell-free vaccine Oka strain and 50% cytotoxic concentration in human fibroblasts were 16.9 µM and more than 100 µM, respectively. Treatment with 45B5 decreased viral DNA synthesis and IE62 expression weakly but significantly. All 45B5-resistant viral clones isolated were found to have at least one mutation in ORF54 that encodes the portal protein. There were no effects on interaction between the portal and scaffold proteins. Thus, 45B5 may inhibit nuclear delivery of viral DNA.
In order to build the system which enables voice training interactively between the user and system, it is required to output the singing voice with rich sound as a teacher sound. Since the user listen to his own bone-transmitted sound as well as his airtransmitted sound when he utters, it is ideal to mix and output the bone-transmitted sounds with the air transmitted sounds of the teacher sound at the same mixing rate where the user actually listens to his singing voice. Here we present the result of investigation what rate of the air-transmitted and bone-transmitted sounds matches the natural situation of listening in utterance.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.