We report a case of a mucoepidermoid carcinoma associated with a maxillary cyst. The patient was an 18-year-old man presenting with the chief complaint of left buccal swelling. The left maxillary third molar was semi-impacted in the direction of the crown on the buccal side. Orthopantomography revealed a cystic radiolucency extending over a wide area, ranging from the left maxilla to the maxillary sinus and nasal cavity. Computed tomography revealed a multilocular lesion surrounded by a thin shell of bone. Biopsy findings revealed a cystic lesion, but the cause could not be identified preoperatively. The cystic lesion was resected under general anesthesia. The lesion was multilocular and surrounded by a bone shell, and had expanded into the maxillary sinus. At the same time, indurated soft tissue adhering strongly to the palatine bone on the inferior palatine side of the lesion was resected. Histopathological examination showed a cystic lesion and mucoepidermoid carcinoma. An additional resection was planned and the maxilla partially resected. Mucoepidermoid carcinomas usually occur in the parotid and minor salivary glands, but in rare cases appear in the center of a jaw bone, almost always in the mandible. In the present case, the carcinoma was associated with a cystic lesion believed to have developed from maxillary bone and involved an impacted tooth adjacent to the tumor. This suggested a central mucoepidermoid carcinoma in the maxillary cyst. Postoperatively, the missing teeth have been replaced with a denture and the course has been good, with no recurrences or metastases identified.
The infratemporal fossa is bordered superiorly by the infratemporal surface of the greater wing of the sphenoid bone and part of the temporal bone; medially by the lateral plate of the pterygoid process of the sphenoid bone; and anteriorly by the posterior surface of the maxilla. As it is completely surrounded by bone, it is frequently difficult to determine whether an abscess is present by direct visual observation or palpation alone. We report an extremely rare case of an infratemporal fossa abscess arising from chronic maxillary osteomyelitis developing after extraction of a maxillary molar. Despite drainage during initial oral anti-inflammatory treatment, pus continued to drain from the wound over a long period of time. This drainage ended when the eroded bone of the maxillary tuberosity on the affected side was curetted in a secondary procedure. The harvested bone tissue exhibited histological findings of chronic osteomyelitis. This suggests that the route of infection involved acute transformation of maxillary osteomyelitis by odontogenic infection advancing posteriorly and superiorly.
Sotos syndrome is inherited in an autosomal-dominant manner and is characterized by increased birth weight, excessive growth, advanced bone age, and distinctive facial features, including dolichocephaly, hypertelorism, and a prominent mandible. We treated a jaw deformity due to Sotos syndrome consisting of malocclusion due to a narrow maxillary dental arch and mandibular retrusion from hypoplasia of the rami. The patient was a 17-year-old man. Malocclusion due to a narrow maxillary dental arch and mandibular retrusion was diagnosed. Rapid maxillary expansion with Lines corticotomy and mandibular advancement with distraction osteogenesis were performed. The maxilla was expanded laterally a total of 3 mm and the mandible prolonged 12 mm in the posterior area of the mandibular body. Subsequently, orthodontic treatment was continued. At present, 5 years after surgery, occlusion remains good and stable.
Essential thrombocythemia (ET) is a myeloproliferative neoplasm characterized by an increase in platelets due to abnormalities in bone marrow hematopoietic stem cells. Control of platelet count and antithrombotic therapy are important in the perioperative period because ET could cause bleeding and thrombosis. We report a case of performing surgery on mouth floor cancer accompanied by ET. A 70-year-old man was referred to our hospital in September 2016 for the indication of a tumor in the right mouth floor. A biopsy showed a pathological diagnosis of squamous cell carcinoma. The clinical diagnosis from imaging examinations was mouth floor cancer T2N1M0. He had been treated with hydroxycarbamide (HU) and dipyridamole since the diagnosis of ET in 2004. The platelet count was 94.1×10 4 / l at the preoperative blood test, so we increased the dose of HU before surgery. As a result, the count decreased to 50.4×10 4 / l on the day of the surgery. Also, we stopped dipyridamole before surgery. He underwent tracheostomy, functional neck dissection, partial resection of the mouth floor and tongue, and reconstruction with a radial forearm free flap in November 2016. When the platelet count increased postoperatively, HU was resumed. Furthermore, daltepalin sodium was started intravenously at the time when the amount of bleeding decreased. He had no perioperative complications due to the control of platelet count or antithrombotic therapy.
Studies over time have shown that green tea catechin (GTE) from tea extracts possesses various bioactivities, including anticarcinogenic activity (antitumorpromot-ing activity, suppression of cancer cell growth, induction of apoptosis) , sealing effects (suppression of binding to carcinogenic promoters/hormone receptors) , antimutagenicity (antiinitiation activity, anticancer agent, suppression of DNA adduct formation) , inhibition of angiogenesis, suppression of gene expression (cmyc, c -Hras) , and suppression of inflammatory cytokines (TNFα, IL -1)
Conclusions: Based on this comparatively large cohort of successive nonmetastatic osteosarcoma patients experience for over 2 decades, we conclude that besides histological response, female gender, ECOG -PS, compliance, and FN are reliable novel, early phase predictors, and merits further exploration to establish their role.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.