Nodular hepatocellular carcinoma (HCC) is characterized by the presence of a pseudocapsule (constructed usually from connective fibrous tissue) that appears hypointense on T1- and T2-weighted spin-echo (SE) and gradient-echo (GE) MR imaging sequences without a contrast medium. The presence of vascular structures inside the tumor, which are verified by histological exam, affects enhancement of the PC after administrating the contrast medium: The impregnation is more evident in the dynamic study but also persists on the delayed T1-weighted SE images. The accuracy of MR in detecting the pseudocapsule of HCC and contrast enhancement of the pseudocapsule during dynamic studies were evaluated and related to pathological findings. Thirty-seven HCC were examined in 33 patients and afterwards resected. In capsulated nodules, besides usual hematoxylin, eosin, and trichrome stainings, histochemical and immunohistochemical methods were performed. On a 1.5-T MR unit, T1- and T2-weighted SE and GE FLASH 2D sequences after intravenous injection of Gd-DTPA (dynamic study) were used. In a later phase, T1-weighted SE sequences were repeated. Histologically, the pseudocapsule (thickness 0.2-6 mm) was present in 26 of 37 nodules (70%). The dynamic study was the most suitable technique to show the pseudocapsule, which was recognized in 80.7% (21 of 26 nodules). In 5 of 26 cases, the pseudocapsule, not demonstrated by MR, was thinner than 0.4 mm. In 16 of 21 cases, in the early portal phase (30-60 s), the pseudocapsule had an early enhancement, which was more evident later; in 5 of 21 cases the enhancement was observed only in the late portal phase (1-2 min). At histological examination, 14 of 16 pseudocapsules with early enhancement showed a more prominent vasculature than those with enhancement in the equilibrium phase. Magnetic resonance was a reliable tool in demonstrating the pseudocapsule of HCC. The histological examination demonstrated a good correlation between the enhancement behavior and the vessel number of the pseudocapsule.

<p>The dissemination of the tangible and intangible values of heritage building represents one of the most important objectives in the field of Digital Cultural Heritage (DCH). In recent years, different studies and research applied to heritage monuments have shown how it is possible to improve the awareness of the architectural heritage through the integration of latest developments in the field of 3D survey, 3D modelling, Building Information Modeling (BIM) and eXtended Reality (XR). On the other hand, this digital workflow requires a huge amount of data sources and a holistic approach to reach a high level of information sharing coming from different disciplines and sectors such as restoration, geomatics, 3D virtual museums and serious gaming. In conjunction with entertainment software and gaming, this research shows the main results obtained during the generative process of digital environments oriented to improve the level of information and to enrich the contents coming from the informative models. The case study is represented by one of the most important Lombard monuments: the Basilica of Sant’Ambrogio in Milan. This study, starting from the 3D survey and the data collection of the historical records of the church, improves the creation of an XR experience that reaches a new level of interactivity for different types of devices (desktop, mobile, VR headset) and users (experts, non-experts).</p><p><strong>Highlights:</strong></p><ul><li><p>Generative modelling requirements and novel grades of generations (GOG) and accuracy (GOA) are presented in order to improve the digitisation of built heritage from the 3D survey, reducing time and costs of the scan-to-BIM process.</p></li><li><p>The holistic value of generative modelling allows experts to create digital worlds able to faithfully and accurately represent the detected reality and improve new immersive environments for Virtual Reality (VR) and Augmented Reality (AR) projects.</p></li><li><p>Immersive environments are created with a mixture of the latest generation software and hardware, allowing users to discover the hidden historical values of built heritage with new levels of interactivity and information.</p></li></ul>

In recent years, many efforts have been invested in the cultural heritage digitization: surveying, modelling, diagnostic analysis and historic data collection. Nowadays, this effort is finalized in many cases towards historical building information modelling (HBIM). However, the architecture, engineering, construction and facility management (AEC-FM) domain is very fragmented and many experts operating with different data types and models are involved in HBIM projects. This prevents effective communication and sharing of the results not only among different professionals but also among different projects. Semantic web tools may significantly contribute in facilitating sharing, connection and integration of data provided in different domains and projects. The paper describes this aspect specifically focusing on managing the information and models acquired on the case of vaulted systems. Information is collected within a semantic based hub platform to perform cross correlation. Such functionality allows the reconstructing of the rich history of the construction techniques and skilled workers across Europe. To this purpose an ontology-based vaults database has been undertaken and an example of its implementation is presented. The developed ontology-based vaults database is a database that makes uses of a set of ontologies to effectively combine data and information from multiple heterogeneous sources. The defined ontologies provide a high-level schema of a data source and provides a vocabulary for user queries.

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This paper describes the case study of the damaged church of St. Francesco in the hamlet of Arquata del Tronto (Italy) that was struck by the earthquake in 2016. The municipality commissioned the research to support the preliminary design of the preservation plan. The first digitisation level has been started from the richness of surveying data acquired from static and dynamic terrestrial laser scanning (TLS), and photogrammetry, overcoming challenging constraints due to the scaffolding covering the surfaces. The geometric survey allowed authors to acquire massively geometric and material information supporting the three-dimensional (3D) volume stratigraphic and the creation of the Heritage Building Information Modelling (HBIM). The paper proposes a shift from the Geographic Information System (GIS)-based analysis of the materials toward spatial HBIM management. Building Archaeology is turned into HBIM 3D volume stratigraphy, overcoming the bidimensional (2D) surface mapping, in favour of a 3D understanding of direct and indirect sources. Material mapping is added to HBIM 3D volume stratigraphy, and each stratigraphic unit (SU) has its proprieties. The 3D volume stratigraphic database has been designed to collect the data on the unit detection at three levels (direct sources data collection, indirect data documentation, the relation among the BIM object elements). A common data environment (CDE) has been set up to share the 3D volume informative models that can be accessed, and all the information gathered. The knowledge transfer using the eXtended reality (XR) has been devoted to the citizen and tourist fruition, enhancing the comprehension of difficult concepts like the SUs to support a better critical 3D reconstruction. It includes the phases of construction across time-lapse documentation that validates related information within the building archaeology informative models leaving spaces to the uncertainty and documenting the relationship established so far thanks to the direct and indirect sources. The result obtained is a live digital twin that can be continuously updated, which justifies the costs and time demanding of HBIM despite 2D drawings.Highlights: • 3D survey and scan-to-HBIM process for the creation of a digital twin were oriented to the preliminary design of the preservation plan of the church of St. Francesco in Arquata del Tronto (Italy). • Stratigraphy is investigated and oriented towards a digitisation process to share different levels of knowledge through new forms of digital-sharing such as Common Data Environment (CDE) and cloud-based BIM platform. • eXtended reality (XR) is the final tool to reach new levels of communication and a wider audience characterised by experts in the construction sector and virtual and non-expert tourists.

This essay describes the combination of 3D solutions and software techniques with traditional studies and researches in order to achieve an integrated digital documentation between performed surveys, collected data, and historical research. The approach of this study is based on the comparison of survey data with historical research, and interpretations deduced from a data cross-check between the two mentioned sources. The case study is the Basilica of S. Ambrogio in Milan, one of the greatest monuments in the city, a pillar of the Christianity and of the History of Architecture. It is characterized by a complex stratification of phases of restoration and transformation. Rediscovering the great richness of the traditional architectural notebook, which collected surveys and data, this research aims to realize a virtual notebook, based on a 3D model that supports the dissemination of the collected information. It can potentially be understandable and accessible by anyone through the development of a mobile app. The 3D model was used to explore the different historical phases, starting from the recent layers to the oldest ones, through a virtual subtraction process, following the methods of Archaeology of Architecture. Its components can be imported into parametric software and recognized both in their morphological and typological aspects. It is based on the concept of LoD and ReverseLoD in order to fit the accuracy required by each step of the research.

The paper focuses on new opportunities of knowledge sharing, and comparison, thanks to the circulation and re-use of heritage HBIM models by means of Object Libraries within a Common Data Environment (CDE) and remotely-accessible Geospatial Virtual Hubs (GVH). HBIM requires a transparent controlled quality process in the model generation and its management to avoid misuses of such models once available in the cloud, freeing themselves from object libraries oriented to new buildings. The model concept in the BIM construction process is intended to be progressively enriched with details defined by the Level of Geometry (LOG) while crossing the different phases of development (LOD), from the pre-design to the scheduled maintenance during the long life cycle of buildings and management (LLCM). In this context, the digitization process—from the data acquisition until the informative models (scan-to-HBIM method)—requires adapting the definition of LOGs to the different phases characterizing the heritage preservation and management, reversing the new construction logic based on simple-to-complex informative models. Accordingly, a deeper understanding of the geometry and state of the art (as-found) should take into account the complexity and uniqueness of the elements composing the architectural heritage since the starting phases of the analysis, adopting coherent object modeling that can be simplified for different purposes as in the construction site and management over time. For those reasons, the study intends (i) to apply the well-known concept of scale to the object model generation, defining different Grades of Accuracy (GOA) related to the scales (ii) to start fixing sustainable roles to guarantee a free choice by the operators in the generation of object models, and (iii) to validate the model generative process with a transparent communication of indicators to describe the richness in terms of precision and accuracy of the geometric content here declined for masonry walls and vaults, and (iv) to identifies requirements for reliable Object Libraries.

<p><strong>Abstract.</strong> One of the challenges of the Digital Cultural Heritage (DCH) field is the creation of coherent HBIMs and the dissemination of the collected historical data. The latest development of new technologies has the great potential to realise virtual content-based immersive experiences that are easily available by both experts and non-expert users. On the other hand, they require specific skills and a holistic approach to the study of the building that involves different disciplines.</p><p>The research that has been carried out for the last five years on one of the greatest monuments in Milan, the Basilica of Sant'Ambrogio, adopted this comprehensive methodology. Although the church is a very well-known building, its turbulent history remains in a certain aspect hidden to the large public. This paper shows the workflow that has been developed for the Basilica, starting from the 3D survey to the historical data acquisition and the study on the church itself, based on a ‘virtual subtraction process’, till the creation of a Virtual Reality experience. This one is the first step of a wider project on eXtended reality (Virtual/Mixed/Augmented Reality) that intends to make the gathered knowledge of the Basilica available to the public.</p>