Background: Ursodeoxycholic Acid (UDCA) is a bile acid widely used in the treatment of cholestatic liver disorders. Few studies have been conducted using UDCA in indirect hyperbilirubinemia. We planned this study to know the role of Ursodeoxycholic acid on indirect hyperbilirubinemia in neonatesMethods: The study was conducted in Department of Paediatrics and Neonatology at Eras Lucknow Medical College and Hospital from November 2015 to September 2017 in 96 term neonates with total bilirubin levels in phototherapy range. They were randomized into 3 Groups receiving either phototherapy only or UDCA at 10mg/kg/day or 20mg/kg/day along with phototherapy.Results: Present study showed that there was a higher rate of fall and less duration of phototherapy required in children receiving UDCA. However, there was no difference in the group receiving 10mg vs 20 mg /kg/day Conclusions: We conclude that by giving UDCA at 10mg/kg/day along with phototherapy in neonate with indirect hyperbilirubinemia leads to faster resolution of hyperbilirubinemia.
Vivax malaria is in general described and considered as benign as it less likely causes severe illness, compared to malaria caused by Plasmodium falciparum (P.falciparum)species. Of late, there have been increasing evidences of Plasmodium Vivax (P.vivax) too causing severe disease and leading to poor outcomes.. We report a case of severe P vivax malaria in a 12 year old child complicated by Acute respiratory distress syndrome(ARDS)
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