In the present study, a novel series of N5-(3-substituted benzylidene)-N4-phenyl pyrimidine-4,5-diamine / N5-(2- substituted benzylidene)-N2,N2-dimethyl-N4-phenyl pyrimidine-2,4,5-triamine were synthesized by using the starting ingredient formimidamide/ 4-(dimethylamino) benzimidamide and it was characterized by IR, 1H NMR and Mass spectral analyses. The synthesized compounds aiming towards the development of potential antimicrobial agents in this connection the screening of structures of the synthesized scaffolds were possessing their antimicrobial activity against G+ve bacteria Stap.aureus, Stap.epidermidis, Micr.luteus and Baci.cereus, G-ve bacteria Ech.coli, Pseu.aeruginosa & Kleb.pneumoniae and fungi Asp.niger & Asp.fumigatus. Among all the synthesized compounds four derivatives were showed the highest significant zone of inhibition towards G+ve, G-ve bacteria and fungi microbial growth.
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