An advantageous synthesis of 5-substituted 1H-tetrazoles has been developed by treatment of organic nitriles with NaN 3 in the presence of iodine or the heterogeneous catalyst, silicasupported sodium hydrogen sulfate (NaHSO 4 ·SiO 2 ).
A wide range of benzo[c]cinnolines are prepared through a sequential C-C and C-N bond formation by means of an oxidative C-H functionalization. The reaction proceeds via the C-arylation of 1-arylhydrazine-1,2-dicarboxylate with aryl iodide using Pd(OAc)2/AgOAc followed by an oxidative N-arylation in the presence of PhI/oxone in trifluoroacetic acid. It is entirely a new strategy to generate the benzo[c]cinnoline libraries with a diverse substitution pattern.
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