Here, we present a new handheld multiphoton endomicroscopic system designed for tumor diagnosis in the head and neck region. It consists of an approximate 25-cm-long rigid endomicroscopic probe with two variants (0° and 45° bended tip), connected to a handheld scan-head. The system can achieve a field of view ⪆600 µm for Coherent Anti-stokes Raman Scattering (CARS) and other nonlinear imaging modalities by a non-de-scanned detection and using a de-scanned confocal imaging channel to detect light from tissue labeled with Indocyanine Green (ICG). Furthermore, high-power femtosecond laser pulses can be transmitted through the system for precise tissue ablation which was considered in the optical design of the probe.

No abstract

Here, we present a new handheld multiphoton endomicroscopic system for tumor diagnosis in the head and neck region. It consists of an approx. 25 cm long rigid endomicroscopic probe with two variants (0° and 45° bended tip), connected to a handheld scan-head. The system can achieve a field of view > 600 μm for coherent anti-Stokes Raman scattering (CARS) and other nonlinear imaging techniques by a non-descanned detection channel, and laser confocal imaging with indocyanine green (ICG) by a descanned detection channel. Furthermore, high-power femtosecond laser pulses can be transmitted through the system for precise tissue ablation without the risk of damaging the optical components.