Effect of high-dose methotrexate (MTX) on children with acute lymphoblastic leukemia (ALL) with different subtypes and disease courses was investigated. A retrospective analysis of 207 children with ALL who were admitted to the People's Hospital of Pingyi County from March 2014 to June 2017 was carried out. According to the subtype of the disease, the children were divided into two groups. B-lineage group: ALL occurred in B-lineage lymphocytes (n=128); T-lineage group: ALL occurred in T-lineage lymphocytes (n=79). According to the disease course, the children were divided into three groups. High-risk group: disease course >15 days (n=67); moderate-risk group: disease course >8 and <15 days (n=58); low-risk group: disease course <8 days (n=82). The plasma concentration, calcium formyltetrahydrofolate (CF) rescue times and adverse reactions were compared at 12 h (T1), 48 h (T2), and 72 h (T3) after MTX infusion. The plasma concentration in B-lineage group was significantly higher than that in the T-lineage group at T2 and T3 (P<0.05). The incidence of adverse reactions in children with ALL in the B-lineage group was significantly higher than that in the T-lineage group (P<0.05). The CF rescue times in high-risk group were more than that in moderate- and low-risk groups (P<0.05). The incidence of adverse reactions in the high-risk group was significantly higher than that in the moderate- and low-risk groups (P<0.05), and in the moderate-risk group was significantly higher than that in the low-risk group (P<0.05). Compared with T-lineage ALL children, high-dose MTX causes more toxic injury to B-lineage ALL children. During clinical application of MTX in the treatment of ALL, close attention should be paid to the changes of the vital signs of patients, and timely CF rescue should be performed.
The effect of a synergistic flame‐retardant system with epoxy resin microcapsule modified ammonium polyphosphate (MAPP) as the primary flame retardant, and strontium carbonate (SrCO3) as the synergistic agent on the flame retardancy of polypropylene (PP) were studied. The flame‐retardant performance of the prepared PP composite samples was analyzed by vertical combustion test (UL94), limiting oxygen index (LOI) test, cone calorimeter test, infrared chromatography (FT‐IR), thermogravimetric analysis (TGA), scanning electron microscopy (SEM), and other technical means. The results showed that when the addition amount of SrCO3 was 1.5 wt%, the LOI reached 36.1%, and the UL‐94 test reached V‐0. Compared with no SrCO3 added sample, the peak heat release rate (PHRR) dropped from 395 to 378 kW/m2. The SEM data showed that the addition of SrCO3 enabled the flame‐retardant system to form a firmer char layer. The TGA data showed that SrCO3 catalyzes the MAPP reaction to form a cross‐linked structure and forms a bridge bond between the two phosphate groups to promote a stable carbon layer. Compared with no SrCO3 added sample, PP composite's tensile strength was increased from 26.78 to 29.42 MPa. Thus, a suitable amount of SrCO3 had a synergistic effect on the flame retardancy of the PP composite and had improved the system's mechanical properties.
ObjectivesPolycyclic aromatic hydrocarbons (PAHs) have been proven to be a risk factor for cardiovascular disease in coke oven workers, and increased plasma viscosity is a signal for higher risk of catching up cardiovascular disease. We want to explore whether the plasma viscosity is affected by the concentration of PAHs.DesignOur study is a cross-sectional dose–response study.SettingParticipants in this study came from a coke plant in Taiyuan, Shanxi.ParticipantsWe used data of 693 coke oven workers in Taiyuan.Primary and secondary outcome measuresWe assumed that plasma viscosity would increase as the concentration of PAHs metabolites in urine increases. We found that 2-hydroxyfluorene (OHFLU2) and plasma viscosity have a stable linear relationship in different statistical methods.ResultsWe found that plasma viscosity increased by 1.14 (mPa.s,30/s) for each ng/mL of 2-OHFLU urinary (correlation coefficient range: 0.54–1.74, p<0.05).ConclusionsThe results of this study could provide evidence for coke oven workers to prevent cardiovascular disease by checking whether plasma viscosity is elevated.
Rheumatoid arthritis (RA) is a chronic and progressive autoimmune disease. Lamiophlomis rotata (L.rotata)( Benth.) Kudo, an essential medicinal plant in traditional Tibetan medicine, is useful in treating RA. The purpose...
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