A novel nisin-loaded poly (vinyl alcohol)/ wheat gluten/zirconia (Nisin-PVA/WG/ZrO 2 ) nanofibrous membranes was prepared via electrospinning technique. The drug carrier PVA/WG/ZrO 2 nanofibers showed a increase in average diameter with the increase of ZrO 2 content, and the fibers tended to conglutinate when ZrO 2 content reached 12 wt% and above. Hydrogen and Zr-O-C bonds existed among PVA, WG, and ZrO 2 units improved the thermal stability of polymeric matrix. The loading dosage of nisin caused no significant changes in the size and morphology of nanofibers at nisin content below 6 wt%. The antimicrobial activity and release experimental results showed that the nisin-PVA/WG/ZrO 2 nanofibrous membranes displayed well-controlled release and better antimicrobial activity against Staphylococcus aureus, and the nisin release from the nanofibers could be described by Fickian diffusion model. In our opinions, these nisin-PVA/ WG/ZrO 2 nanofibrous membranes may have potential as a new nanofibrous membrane in drug delivery, wound dressing, and active food packaging.

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The in vitro bioactivity of scaffolds, and the adhesion, mineralization, viability and proliferation of hFOBs on gelatin/MWNTs/HA nanofibrous scaffolds.