Background: Patients with high-risk neuroblastoma (NB) have a poor prognosis. The prognostic signi cance of in ammatory biomarker-based nomograms for children with NB has not been previously studied.Methods: Part of patients diagnosed with NB in our center from January 2016 to March 2022 were included in the study. In ammatory biomarkers were primary outcome measures, including C-reactive protein (CRP), ferritin, neutrophil to lymphocyte ratio (NLR), and lymphocyte to monocyte ratio (LMR), platelet to lymphocyte ratio (PLR) and systemic immune-in ammation index (SII). Univariate and multivariate survival analyses were performed to assess the prognostic value of these indicators for overall survival (OS) in NB children, showing the Kaplan-Meier survival curves and plotting the nomogram. C-index were used to detect predictability. Results: 93 NB patients were retrospectively analyzed.CRP, ferritin, NLR, PLR, and SII were signi cantly associated with OS of NB patients, while LMR were found to be not predictive of OS for NB patients. The established nomogram is well-calibrated, and the C-index is 0.731. Conclusion: Survival analysis found part of in ammatory biomarkers related to the prognosis of NB. The nomogram could be used as a convenient predictive tool in clinical practice to evaluate the prognosis of NB children at rst diagnosis. Impact 1. CRP, ferritin, NLR, PLR, and SII are associated with the prognosis of neuroblastoma.2. We have created a nomogram that can be used to predict the prognosis of affected children and play a role in determining the treatment plan.3. Our results differ from a previous study in that we increased the sample size for the study and had good internal validation results for the nomogram.
Background: Patients with high-risk neuroblastoma (NB) have a poor prognosis. The prognostic significance of inflammatory biomarker-based nomograms for children with NB has not been previously studied. Methods: Part of patients diagnosed with NB in our center from January 2016 to March 2022 were included in the study. Inflammatory biomarkers were primary outcome measures, including C-reactive protein (CRP), ferritin, neutrophil to lymphocyte ratio (NLR), and lymphocyte to monocyte ratio (LMR), platelet to lymphocyte ratio (PLR) and systemic immune-inflammation index (SII). Univariate and multivariate survival analyses were performed to assess the prognostic value of these indicators for overall survival (OS) in NB children, showing the Kaplan-Meier survival curves and plotting the nomogram. C-index were used to detect predictability. Results: 93 NB patients were retrospectively analyzed.CRP, ferritin, NLR, PLR, and SII were significantly associated with OS of NB patients, while LMR were found to be not predictive of OS for NB patients. The established nomogram is well-calibrated, and the C-index is 0.731. Conclusion: Survival analysis found part of inflammatory biomarkers related to the prognosis of NB. The nomogram could be used as a convenient predictive tool in clinical practice to evaluate the prognosis of NB children at first diagnosis.
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