Prediction to the prognosis of children with neuroblastoma by nomogram based on the first-diagnosed inflammatory markers

Zhang, Yunlong; Zhang, Chenghang; Ma, Yue; Li, Changchun; Zhao, Zhiling; Peng, Liang; Deng, Xiaobin; Zhou, Jianwu; Wang, Shan

doi:10.21203/rs.3.rs-2100392/v1

Cited by 1 publication

(1 citation statement)

References 27 publications

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“…It also discusses its association with sex, weight, age, and neutrophil to lymphocyte ratio (NLR). We chose NLR, because it has been shown to be prognostic in many acute conditions such as cancer, 7 , 8 sepsis, 9 , 10 , 11 , 12 , 13 surgery, 14 , 15 , 16 and even Covid‐19. 17 …”

Section: Introductionmentioning

confidence: 99%

Incidence of neurological complications following pediatric heart surgery and its association with neutrophil‐to‐lymphocyte ratio

Abdshah

Mirzaaghayan

Heidari

et al. 2023

Health Science Reports

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Background and Aims Due to increased rate of open‐heart surgeries in children, postsurgical mortality and morbidities have increasingly gained attention. Neurological complications are some of the most important postsurgical events. However, the number of studies regarding postsurgical neurological complications seems to be inadequate. We aimed to study the incidence of neurological complications following cardiac surgery in the pediatric cardiac intensive care unit (ICU) of the children's medical center. Methods This cross‐sectional study was conducted from March to September 2019. We included all of the children who underwent cardiac surgery and were admitted to ICU at CMC. We collected their demographic data, lab test results (white blood cell count, absolute neutrophile and lymphocyte counts) and calculated their Risk Adjustment for Congenital Heart Surgery (RACHS) score. We then documented neurological adverse events and investigated the associations between those events and the patients' data. Results Of the 267 studied patients, 14 developed neurological complications (5.2%); seven developed chorea (2.6%), four developed seizures (1.5%), and two developed both seizure and chorea (0.7%). One case developed subarachnoid hemorrhage (SAH). We observed that age ( p = 0.000), weight ( p = 0.000), and RACHS score ( p = 0.006) were associated with the development of neurological complications. Additionally, we observed that “neutrophil to lymphocyte ratio” was not associated with the risk of postsurgical neurological complications. Conclusion Younger age, lower weight, and higher RACHS score were associated with neurological complications after operations. Given the importance of postsurgical neurological complications, further investigations should be carried out to cover this issue and discover preventive strategies for such morbidities.

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