A transition-metal-free protocol capable of synthesizing diarylated aniline derivatives is reported. This method could be further employed to prepare aryl alkyl ethers. A wide range of thioethers, anilines, as well as alcohols were tolerated thanks to the mild reaction conditions. The strength of our method was demonstrated by performing a gram-scale reaction (20 mmol) followed by conversion of the nitrile group into synthetically useful aldehyde, ketone, and carboxylic acid.
We describe a general and efficient
protocol for the synthesis
of organophosphine compounds from phenols and phosphines (R2PH) via a metal-free C–O bond cleavage and C–P bond
formation process. This approach exhibits broad substrate scope and
excellent functional group tolerance. The synthetic utilities of this
protocol were demonstrated by the synthesis of chiral ligands via
the various transformations of cyano groups and their applications
in asymmetric catalysis.
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