Increasing sustainability awareness throughout society has sought to bring more atom‐economy and environmentally benign synthetic methods based on simultaneous reaction transformation through ubiquitous C−H and C−O activation. This work reports a Ni‐catalyzed heteroarene C−H/arenol C−OH coupling reaction, which omits the use of strong Lewis‐acid additive and low atom‐economy protecting reagent. The array of arenols and heteroarenes is effective in this protocol using in‐situ activating reagent of pivalic anhydride. Detailed mechanistic studies and identification of intermediate have been carried out to understand the nature of catalytic reactions.
Over the last two decades, phenolic or alcoholic derivatives have been slowly evolved as conceivable replacements to the ubiquitous aryl halides (I, Br, and Cl) in the carbon–carbon cross‐coupling reaction. Nonetheless, there is a daunting challenge in the adoption of CO activation as the toolkit in sustainable molecular synthesis, owing to the high dissociation energy to break the CO bond, thus limiting the scope of reactions for broader application. Therefore, cross‐coupling reaction by incorporating CH bond activation into CO manifold might enrich the reactivity and expand the chemical space for more complex molecule. This article will discuss the reaction methodology and mechanism concerning about nickel and palladium‐promoted tandem CH/CO bond activation for the cross‐coupling reaction.
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