Coupling of Heteroarene and Arenol via Nickel‐Catalyzed C−H/C−OH Activation

Abstract

Increasing sustainability awareness throughout society has sought to bring more atom‐economy and environmentally benign synthetic methods based on simultaneous reaction transformation through ubiquitous C−H and C−O activation. This work reports a Ni‐catalyzed heteroarene C−H/arenol C−OH coupling reaction, which omits the use of strong Lewis‐acid additive and low atom‐economy protecting reagent. The array of arenols and heteroarenes is effective in this protocol using in‐situ activating reagent of pivalic anhydride. Detailed mechanistic studies and identification of intermediate have been carried out to understand the nature of catalytic reactions.