24The usage of antimicrobials for treatment of mink and the occurrence of 25 antimicrobial resistance among the most important bacterial pathogens in mink was 26 investigated. The aim of the study was to provide data, which may serve as a basis for the 27 formulation of recommendations for prudent use of antimicrobials for mink. A total of 164 28 haemolytic staphylococci, 49 haemolytic streptococci, 39 Pseudomonas aeruginosa, 13 29Pasteurella multocida, and 1093 Escherichia coli isolates from Danish mink were included in 30 the study. A high frequency of resistance among S. intermedius was found for tetracyclines 31 (54.7%), followed by penicillin (21.7%), lincosamides (20.4%), macrolides (19.1%), and 32 spectinomycin (18.5%). Very low frequencies of resistance were recorded for other 33 antimicrobials. The highest frequency among the E. coli isolates was recorded for ampicillin, 34 streptomycin, sulphonamides, and tetracyclines, whereas resistance to other antimicrobials 35 was rare. All P. aeruginosa were sensitive to gentamicin and colistin and sensitive or 36 intermediate to enrofloxacin, whereas most isolates were resistant to all other antimicrobials. 37All P. multocida and haemolytic streptococci were sensitive to penicillin. 38There was a steady increase in the use of antimicrobials during the period 2001 -2006, the 39 majority of the prescribed amount being extended spectrum penicillins followed by 40 aminoglycosides, sulphonamides with trimethoprim, and macrolides. 41 42 43
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