No abstract

Objective To assess prospectively the risk of fetal loss associated with chorionic villus sampling (CVS) and amniocentesis (AC) following combined first-trimester screening (cFTS) for Down syndrome.Methods This was a nationwide population-based study (Danish Fetal Medicine Database, 2008-2010

Objectives Targeted non-invasive prenatal testing (NIPT)tests

No abstract

Women older than 40 years have a higher risk of chromosomal abnormalities, miscarriage, and birth before 34 weeks of gestation than younger women and should be monitored accordingly. No increased risk was observed for stillbirth and other congenital malformations. Several factors increase the risk of adverse pregnancy outcomes, but advanced maternal age drives a high proportion of the total risk score.

No abstract

(Obstet Gynecol 2018;131:457–463) Previous studies examining associations between advanced maternal age and adverse pregnancy outcomes have conflicting findings, are inadequately powered, or are prone to bias. The authors of the present study thereby examined the possible associations between advanced maternal age (above 35 y of age) and adverse pregnancy outcomes in a large population-based cohort of pregnant women in Denmark, followed from first trimester to delivery or termination of pregnancy. The authors also predicted risk estimates of a composite adverse pregnancy outcome, to identify whether certain groups of parturients are at risk for select adverse pregnancy outcomes.

In a clinical setting with efficient cFTS, contingent screening offering women with a cFTS risk of ≥ 1 in 100 an invasive test and women with a risk from 1 in 100 to 1 in 1000 a cfDNA test had the same sensitivity for T21, T18 and T13, but significantly increased specificity, when compared with offering an invasive test to all women with a risk of ≥ 1 in 300. Implementing contingent screening would therefore reduce significantly the number of invasive tests performed at no loss of sensitivity. Copyright © 2017 ISUOG. Published by John Wiley & Sons Ltd.