Microcantilever-based biosensors are a promising tool to detect biomolecular interactions in a direct way with high accuracy. We show the development of a portable biosensor microsystem able to detect nucleic acid hybridization with high sensitivity. The microsystem comprises an array of 20 micromechanical cantilevers produced in silicon technology, a polymer microfluidic system for delivery of the samples, an array of 20 vertical cavity surface emitting lasers (VCSELs) with collimated beams thanks to an integrated microlens array, an optical coupling element to provide the optical path required, and chips with the photodetectors and the CMOS circuitry for signal acquisition and conditioning, capable of measuring the cantilever deflection with sub-nanometer resolution. Robust immobilization and regeneration procedures have been implemented for the oligonucleotide receptor sequences. In a further innovation, an optical waveguide cantilever transducer has been also developed in order to improve the final performance of the device. This has a number of advantages in terms of a simple optical geometry and improved sensitivity.
MPB has developed a 10W Polarization Maintaining Optical Fiber amplifier (1550 nm) for space applications. The prototype is based on three stages of optical amplification with photodiodes at each stage, monitoring the output power. It includes the control electronics and software with feedback loops to dynamically control and monitor the amplifier. The design had to overcome many challenges to comply with the mechanical, thermal, radiation, and vacuum requirements for the LEO satellite space environment, while at the same time meeting the price targets for LEO constellations by maximizing the use of commercial off the shelf (COTS) components. The following were the main challenges: a) to effectively dissipate the heat generated (75-90 W); b) to select radiationtolerant electronics to drive the needed electrical current; c) to source and effectively implement components, such as the combiners and isolators, in the high power optical path compatible with vacuum at 10W output. The major challenge with regard to heat management was to find an optimal method to dissipate the heat from the third stage (high power) Erbium Ytterbium Doped Fiber. Commonly, this fiber is spooled on an Aluminium spool. The difference in the Constant Temperature Extension (CTE) between the fiber (low) and Aluminium (high) leads to a detachment of the fiber at low temperature with a high risk of breaking the fiber when passing from OFF to ON. At high temperatures, the Aluminium extends much more than the fiber, leading to an over tension on the fiber with a high risk of mechanical breakage. Different designs of the spool, supports inside the box, selection of materials, and process implementations were tried. An innovative, proprietary method was developed to satisfy this requirement. The unit successfully passed performance testing between -20°C and +40°C in vacuum with 10W output, with a wall plug efficiency of 11%. The lower temperature limitation was due to the specification of the high-power laser diodes. The higher temperature was limited by the local heating and risk of mechanical breaking of the third-stage COTS combiner and isolator. Vibration and mechanical shock are not foreseen to be an issue. The simulation demonstrated the prototype is complying with these requirements. Moreover, MPB has built similar instruments at lower power levels that have successfully passed these qualification tests. The components used were available as COTS products, including the radiation-tolerant electronics. All the components were qualified individually for > 30 krad, in vacuum, and for the temperature range -35°C to +65°C except for the highpower laser diodes which were limited to -25°C. MPBC is continuing the qualification, implementing minor design changes, in order to satisfy the complete temperature range (-35°C to +65°C).
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