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The intention of conducting collaborative multidisciplinary research on records of psychotherapy imposes many potentially incompatible constraints. At the core lies the challenge of segmenting materials into units suitable for very different research methods while nevertheless ensuring comparison and convergence of results across a diverse array of measures. We examine issues of segmentation, present a coordinated system based on segmentation of psychotherapy transcripts by communicated meaning, and describe applications of the approach. Introduction: The Problem of Segmentation and Multunethod AnalysesCollaborative, multimethod research is needed to address many research questions (Brewer & Hunter, 1989;Murray, 1963) and is an important trend in psychotherapy research (Russell, 1987). But measures of relevant constructs are usually applied to different units (Kiesler, 1973). Even though it may be generally agreed that thematic content-what is communicated in therapy-is centrally important, coordinating various methods and measures has always been a sticky problem.