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179monochloroacetic acid, and within 2 hours almost completely abolished. The effect of di-and trichloroacetic acids, while clearly defined, is much weaker and more delayed. It is important to note that here, as at all other concentrations studied, the order of decreasins effect on respiration is : monochloroacetic acid > dichloroacetic acid > trichloroacetic acid. .Acetic acid in the range of 0.01M to 0.001JI showed no effect.Within the range of 0.001pIl to 0.03M, the depression of respiration by mono-and dichloroacetic acids is maximal; there is no indication of a progressively increasing effect with increasing concentration. Within the range of 0.001M to 0.00005M there is a gradually decreasing effect, which ceases below 0.00005M for both acids. This is a concentration of the order of 5 to 10 pg per milliliter of Ringer solution. ,4t a concentration below 0.005M no effect of trichloroacetic acid has been noted, and at 0.01M evidences of tissue coagulation have been seen.Summary. At the concentrations studied monochloroacetic acid produces a marked depression in the respiration of mouse liver slices. The order of decreasing effect of the 3 acids is : monochloroacetic > dichloroacetic > trichloroacetic. Acetic acid has no effect.

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