Skin-mounted soft electronics incorporating high-bandwidth triaxial accelerometers can provide broad classes of physiologically relevant information, such as mechanoacoustic signatures of underlying body processes (such as those captured by a stethoscope) and precision kinematics of core body motions. Here, we describe a wireless device designed to be conformally placed on the suprasternal notch for the continuous measurement of mechanoacoustic signals, from subtle vibrations of the skin at accelerations of ~10 −3 m•s −2 to large motions of the entire body at ~10 m•s −2 , and at frequencies up to ~800 Hz. Because th measurements are a complex superposition of signals that arise from locomotion, body orientation, swallowing, respiration, cardiac activity, vocal-fold vibrations and other sources, we used frequency-domain analysis and machine learning to obtain, from human subjects during natural daily activities and exercise, real-time recordings of heart rate, respiration rate, energy intensity and other essential vital signs, as well as talking time and cadence, swallow counts and patterns, and other unconventional biomarkers. We also used the device in sleep laboratories, and validated the measurements via polysomnography. Natural processes of the human body yield a multitude of mechano-acoustic (MA) signals, many of which strongly attenuate at the skin-air interface 1-5. Motions with amplitudes and Lee et al.

Thin, soft, skin-like sensors capable of precise, continuous measurements of physiological health have broad potential relevance to clinical health care. Use of sensors distributed over a wide area for full-body, spatiotemporal mapping of physiological processes would be a considerable advance for this field. We introduce materials, device designs, wireless power delivery and communication strategies, and overall system architectures for skin-like, battery-free sensors of temperature and pressure that can be used across the entire body. Combined experimental and theoretical investigations of the sensor operation and the modes for wireless addressing define the key features of these systems. Studies with human subjects in clinical sleep laboratories and in adjustable hospital beds demonstrate functionality of the sensors, with potential implications for monitoring of circadian cycles and mitigating risks for pressure-induced skin ulcers.

Capabilities for continuous monitoring of pressures and temperatures at critical skin interfaces can help to guide care strategies that minimize the potential for pressure injuries in hospitalized patients or in individuals confined to the bed. This paper introduces a soft, skin-mountable class of sensor system for this purpose. The design includes a pressure-responsive element based on membrane deflection and a battery-free, wireless mode of operation capable of multi-site measurements at strategic locations across the body. Such devices yield continuous, simultaneous readings of pressure and temperature in a sequential readout scheme from a pair of primary antennas mounted under the bedding and connected to a wireless reader and a multiplexer located at the bedside. Experimental evaluation of the sensor and the complete system includes benchtop measurements and numerical simulations of the key features. Clinical trials involving two hemiplegic patients and a tetraplegic patient demonstrate the feasibility, functionality and long-term stability of this technology in operating hospital settings.

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