The main discussion on the process of development communication as acore component of a sustainable development project at the TswaingCrater Museum near Pretoria. The arlicle initially surveys some localstudies and lessons leamed in an effort to contextua/ise the Tswaingproject. Various approaches, such as Participatory C;ommunication, andDevelopment Support Communication are discussed and related tocommunication structures for the project. New forces in democratisationhave contributed to the crucial role of concepts such as participation,empowerment and emancipation. These approaches rely on normativegoals and standards set by host communities in the development of acommunity's cultural identity, and act as a vehicle for people's selfexpression. Socia-cultural contexts of the developmental andcommunication process are therefore specifically discussed. Finallylessons leamed provide a means of recommending possible solutions todevelopment communication problems.
The origin-binding protein, encoded by the UL9 gene of herpes simplex virus-1 (HSV-1), has the properties of an initiator of DNA replication. In this communication, we report that the UL9 promoter contains a cAMP-response element (CRE). Transient expression analyses show that dibutyryl cyclic AMP, known to elevate intracellular cAMP level, can induce the UL9 promoter in a rat pheochromocytoma cell line (PC12) but not in a non-neuronal human cell line (HeLa). Interestingly, a transcription factor that increases expression of a neuropeptide gene by interacting with CRE can also activate the UL9 promoter independent of cell type. Thus, our data suggest that extracellular stimuli, capable of interacting with the signaling pathway in neuronal cells, can activate UL9 gene expression, and different proteins may regulate UL9 expression in different cell types.
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