Pigmented fungiform papillae of the tongue are a common, yet infrequently considered, variant of normal oral pigmentation. The clinical and histologic features of this entity are described. A random survey of 300 individuals revealed this finding in 30% of Negro women, 25% of Negro men and in several members of other deeply pigmented races. Once the condition is recognized, the clinician need not concern himself nor his patient with a long list of potentially ominous diagnoses.

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Summary.— In 2 patients with toxic epidermal necrolysls due to penicillin and chlorpromazlne respectively, direct immunofluorescent studies revealed intercellular fixation of immunoglobulins and complement globulins confined to the basal cell Kiyer of the epidermis. These findings suggest that the drug binds to intercellular epidermal protein and that the basal cells are the target site of cellular damage in drug‐induced epidermal necrolysls.

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