These findings raise a number of issues pertaining to the use of ImPACT. Invalid performance incidence may increase with large group versus individual administration, use in nonclinical settings, and among those with Attention Deficit-Hyperactivity Disorder or learning disability. Additionally, the older desktop version of ImPACT appears to be associated with a higher rate of invalid performances than the online version. Although ImPACT's embedded invalidity indicators detect invalid performance at a rate of 6% on average, known group validity studies suggest that these measures miss invalid performance approximately 20% of the time when individuals purposefully underperform.

Objectives: Cognitive impairment and apathy are well-documented features of idiopathic normal pressure hydrocephalus (iNPH). However, research examining other neuropsychiatric manifestations of iNPH is scant, and it is unknown whether the neuropsychiatric presentation differs for iNPH patients with comorbid Alzheimer’s disease (AD) versus iNPH without AD. This study aims to advance our understanding of neuropsychiatric syndromes associated with iNPH. Methods: Fifty patients from Butler Hospital’s Normal Pressure Hydrocephalus Clinic met inclusion criteria. Caregiver ratings on the Frontal Systems Behavior Scale (FrSBe) were examined to appraise changes in apathy, executive dysfunction, and disinhibition. Patients also completed cognitive tests of global cognition, psychomotor speed, and executive functioning. AD biomarker status was determined by either amyloid-beta (Aβ) positron emission tomography (PET) imaging or cerebrospinal fluid (CSF) total tau to Aβ-42 ratio. Results: Results revealed clinically significant elevations on the FrSBe’s apathy and executive dysfunction scales and modest correlations among these scales and cognitive measures. Of the 44 patients with available neuroimaging or CSF draw data, 14 presented with comorbid AD. Relative to the iNPH-only group, the iNPH + AD group showed a larger increase from pre-illness to current informant ratings on the executive dysfunction scale, but not the apathy or disinhibition scales. Conclusions: These results replicate and extend prior research by identifying apathy and executive dysfunction as prominent neuropsychiatric symptoms of iNPH and suggest comorbid AD exacerbates dysexecutive behaviors. Future research is warranted to examine the effects of comorbid AD pathology in response to shunt surgery for iNPH, neuropsychiatric symptom changes, and resultant caregiver burden.

Objective The most commonly used computerized neurocognitive test in concussion assessment and management, Immediate Post-concussion and Cognitive Testing (ImPACT), has demonstrated varying and sometimes concerning levels of test–retest reliability. This study aimed to further examine ImPACT’s psychometric qualities and whether ceiling effects may suppress its reliability. Method A total of 300 consecutively selected ImPACT score reports for students attending a secondary school between 2010 and 2015 were reviewed. Test–retest reliabilities for composite scores and subscales were computed using Pearson product moment correlations (r) and intraclass correlation coefficients. To examine the potential influence of ceiling effects, we conducted frequency analyses of scores falling at, or near, the maximum possible score. Results A total of 92 score reports met inclusion criteria. Test–retest reliabilities ranged from 0.42 to 0.69 for composite scores and 0.19 to 0.71 for subscales. Subscales comprising the Verbal and Visual Memory composites evidenced the most prominent ceiling effects. Conclusions Obtained test–retest reliabilities were consistent with a large segment of the literature and add to concerns about ImPACT’s reliability. Furthermore, at least in a select sample, this study identified sizeable ceiling effects that likely diminish the reliability of some composite scores. To mitigate the risk of false-negative errors on post-injury testing, ImPACT users should be cognizant of such ceiling effects. Supplemental, or alternative, approaches to protect against underestimating baseline functioning also warrant consideration.

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Late-career physicians (LCPs) are at risk for cognitive changes that may affect their ability to practice medicine. This review aggregates and discusses research that has examined cognitive functioning among physicians, typically when clinically referred for various medical and psychological reasons that may interfere with their ability to practice medicine. Special consideration is devoted to the role of approaches for examining cognitive functioning (e.g., cognitive screening, cognitive testing, & neuropsychological assessment), normative challenges, and cultural factors that should be considered when evaluating a physician. Based on published studies, there is evidence supportive of the use of cognitive testing and neuropsychological assessment among physicians in a fitness for duty setting. However, prospective studies designed to identify physicians at-risk (i.e., to prevent medical error) are lacking. Additional research is warranted to establish physician-based normative reference groups and aid in test interpretation and prognostication. Moreover, given limitations associated with cognitive testing in isolation, there is a potential role for comprehensive neuropsychological assessment to identify cognitive changes in physicians and provide a supportive pathway to preserve physicians’ ability to practice medicine.

Post-traumatic stress disorder (PTSD) is a prevalent and disabling condition occurring frequently among Veterans. However, among those diagnosed with PTSD, predictors of changes in PTSD symptoms over time remain incompletely characterized. In the current study, we examined 187 post-9/11 Veterans (Mean baseline age = 32.8 years, 87% male) diagnosed with PTSD who participated in two extensive clinical and cognitive evaluations approximately two years apart. Our analyses focused on the association between baseline measures predicting both continuous changes in PTSD symptoms and differences between groups with Improved, Chronic, and Worsened PTSD symptoms, defined by applying clinically meaningful and reliable change approaches. We found that better baseline inhibitory control (Color-Word Inhibition and Inhibition/Switching) and lower lifetime drinking history independently predicted greater PTSD symptom improvements over the two-year period, though current drinking and other clinical and cognitive variables were not significant predictors. Consistent with this, the Improved, Worsened, and Chronic PTSD groups demonstrated significant differences in baseline inhibitory control performance and lifetime drinking history, with the largest differences in drinking behavior in the early-to-mid 20s. We also found that PTSD symptom improvements were not significantly associated with improvements in inhibitory control or appreciable reductions in alcohol use. Together, these findings suggest that alcohol use and inhibitory control may reflect clinically important pre-existing factors rather than effects of PTSD symptomatology. These findings have implications for the treatment of PTSD, including monitoring vulnerable individuals at risk for more chronic PTSD and novel interventions targeting inhibitory control.

The understanding of neuropsychological functioning in pediatric psychiatric inpatient populations is growing, but limited, resulting in interpretive challenges. This study examined the application of multivariate base rate (MVBR) analysis in a clinical sample to appraise its utility in characterizing the frequency of low scores, as well as predictors of low scores, when using a flexible test battery. Participants included 99 children from a psychiatric inpatient unit referred for neuropsychological testing. Children hospitalized with psychiatric disorders exhibited high rates of low scores at varying criteria across the battery of tests. Hierarchical multiple regression analyses revealed that after accounting for demographic and psychiatric factors, intellectual functioning accounted for approximately 26% of the variance in observed low scores. The results suggest that a substantial percentage of this population produces low scores on neuropsychological testing and, consistent with prior research, intellectual functioning is strongly associated with low score frequency. To our knowledge, this is the first study to examine the clinical application of MVBR analysis in a pediatric psychiatric inpatient population using a flexible test battery. Taken together, this investigation highlights the potential clinical utility of MVBR analysis when interpreting neuropsychological performance in clinical pediatric populations.