Background: Musa sapientum, commonly known as banana, is an herbaceous plant of the Musaceae family. Copper-based nanoparticles (Cu-NPs) enhance the scavenging capacity of various antioxidants and improve the treatment of ROS-related diseases. The aim of this study is to evaluate the antioxidant activity of banana stem mediated copper nanoparticles.
Materials and Methods: Banana stems weighing 200 grams were cut into small pieces. These fragments were powdered and mixed with 200 cc of sterile distilled water in a blender. CuCl2H2O (0.5 mmol, 5 mL) was applied to ethanol, and the reaction mixture was allowed to react with 1 M NaOH while stirring. Cu-Nps and the prepared banana stem extract were mixed together. The DPPH assay was used to investigate the antioxidant activity of banana stem mediated Cu-Nps. The percent inhibition values were determined using the formula after the absorbance values were measured with a UV spectrophotometer.
Results: At the highest concentration used in the study, the antioxidant activity of banana stem mediated Cu-Nps was 88.10 percent and that of vitamin C was 92.15 percent. This demonstrated that Cu- Nps mediated by banana stems have a concentration-dependent antioxidant effect.
Conclusion: The antioxidant activity of banana stem mediated Cu- Nps tested here was higher than the standard antioxidant drug vitamin c in lower concentration. In higher concentration, vitamin c standard showed higher antioxidant activity.
Background: Cancer is a major health problem worldwide and still lacks fully effective treatments. As a result, natural-products-based alternative medicines have been developed. Marine algae are a vital part of the marine environment, with high biodiversity and contain a diverse range of useful chemicals.
Aim: Aim of the study was to assess the anticancer activity of Padina gymnospora crude extract against lung cancer cell line
Materials and Methods: The Seaweed P. gymnospora was evaluated for its anti-cancer activity via MTT assay, further, morphological study of the cells was done to check its efficacy. Finally, the results were analyzed by Student's-t-test using MS-Excel, represented as mean ± SD for triplicates. The results were computed statistically (SPSS/10 Software Package; SPSS Inc., Chicago) using one-way ANOVA. The level of statistical significance was set at p<0.05.
Results and Discussion: The results of this study indicate that P. gymnospora has significant anticancer activity. At the highest concentration, 500μl, methanolic crude extracts of P. gymnospora showed the maximum anticancer activity, where the cell viability was only 16.41+7.15. The morphological study also revealed that maximum cell death had occurred in the maximum concentration of the methanolic crude extract of P. gymnospora.
Conclusion: Despite the widespread use of algae-derived compounds and extracts in the food industry, there are still limited anticancer drugs available in the industry. Thus, it is imperative that new drug discovery programs using seaweeds with a much more mechanistic approach are needed.
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