Context
Arginine-vasopressin (AVP) and corticotropin-releasing hormone (CRH) act synergistically to stimulate secretion of adrenocorticotropic hormone (ACTH). There is evidence that glucocorticoids act via negative feedback to suppress AVP secretion.
Objective
Our hypothesis was that a post-operative increase in plasma copeptin may serve as a marker of remission of Cushing Disease (CD).
Design
Plasma copeptin was obtained in patients with CD before and daily on post-operative days 1-8 after transsphenoidal surgery. Peak post-operative copeptin levels and Δcopeptin values were compared among those in remission versus no remission.
Results
Forty-four patients (64% female, 7-55 years old) were included, and 19 developed neither DI nor SIADH. Thirty-three had follow-up at least 3 months post-operatively. There was no difference in peak post-operative copeptin in remission [6.1 pmol/L (4.3-12.1)] versus no remission [7.3 pmol/L (5.4-8.4), p=0.88].. Excluding those who developed DI or SIADH, there was no difference in peak post-operative copeptin in remission [10.2 pmol/L (6.9-21.0)] versus no remission [5.4 pmol/L (4.6-7.3), p= 0.20]. However, a higher peak post-operative copeptin was found in those in remission [14.6 pmol/L (±10.9) vs. 5.8 (±1.4), p=0.03]] with parametric testing. There was no difference in the Δcopeptin by remission status.
Conclusions
A difference in peak post-operative plasma copeptin as an early marker to predict remission of CD was not consistently present, although the data point to the need for a larger sample size to further evaluate this. However, the utility of this test may be limited to those who develop neither DI nor SIADH post-operatively.
Background: As both L- and D-BAIBA are increased with exercise, we sought to determine if circulating levels would be associated with physical performance.
Method: Serum levels of L- and D-BAIBA were quantified in 120 individuals (50% female) aged 20-85 years and categorized as either a “low” (LP), “average“(AP) or “high“ performer (HP).
Association analysis was performed using Spearman (S) and Pearson (P) rank correlation.
Results: Using the Spearman (S) rank correlation, L-BAIBA positively associated with BMI (0.23) and total fat mass (0.19) in the 120 participants, with total fat mass in the 60 males (0.26) but with both BMI (0.26) and BMD (0.28) in the 60 females. In the HP females, L-BAIBA positively associated with BMD (0.50) and lean mass (0.47).
Using the Pearson (P) rank correlation D-BAIBA was positively associated with age (0.20) in the 120 participants and in the LP females (0.49). D-BAIBA associated with gait speed (S 0.20) in the 120 participants. In HP males, this enantiomer had a negative association with appendicular lean/height (S -0.52) and in the AP males with BMD (S -0.47). No associations were observed in HP or AP females, whereas, in LP females, in addition to a positive association with age, a positive association was observed with grip strength (S 0.45), but a negative with BMD (P -0.52, S -0.63) and chair stands (P -0.47, S -0.51).
Conclusions: L-BAIBA may play a role in BMI and BMD in females, not males, whereas D-BAIBA may be a marker for aging.
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