A nerve sheath myxoma involving the breast has been examined by light and electron microscopy, and by immunohistochemical and histochemical methods. Electron microscopically, cells with features indicative of Schwann cells, perineural cells and fibroblasts were identified in the tumour and S-100 protein and vimentin positivity was demonstrated in the tumour cells. The mucoid matrix stained positive for chondroitin-4 or 6-sulphate in keeping with a cartilaginous lesion. These findings are discussed in relation to the uncertain histogenesis and the differential diagnoses of the tumour in the breast.
Central neurocytoma is a rare neuronal tumor that typically occurs in young adults. Infrequently, these tumors exhibit advanced neuronal maturation and glial differentiation, giving rise to a histologically diverse tumor, in contrast to a typical central neurocytoma. We present a novel case of intraventricular central neurocytoma with prominent gangliogliomatous differentiation that developed atypical features upon recurrence after 10 years of follow up in a 10-year-old boy. Our case provides insight into the divergent differentiation capability of a neurocytic tumor and illustrates the diverse histological features of this rare entity.
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