In order to sensitively, selectively, and rapidly detect the constituents relevant to improvised explosive devices (IEDs), the sensing properties of ZnS nanocrystals (NCs) are regulated by tailoring the doping level of Mn2+. The responses of the sensors fabricated by ZnS NCs with different Mn‐doping levels (Mn:ZnS) toward the constituents, such as sulphur powder and black powder, generally increases first and then decreases with the increase of the concentration of doped Mn2+, and reaches the climate with an atomic ratio of 2.23% at room temperature. The sensory array based on eight sensors of Mn:ZnS NCs can realize the detection of two typical military explosives and six constituents relevant to IEDs within 7 s and can recover in 19 s. Furthermore, the fingerprinting of the constituents is achieved by pattern recognizing the inherent kinetics and thermodynamics of interaction between the sensory array and the constituents. Thus, a simple chemiresistive sensing strategy based on semiconductor NCs which can rapidly, supersensitively, and discriminatively detect the constituents relevant to IEDs is explored for the first time.
A new phenylboronic acid based gelator was developed to prepare low-molecular-weight organogel (LMOG), which could interact with several solvents to assemble into a three-dimensional nanofiber network. (1)H NMR spectroscopy study suggests that the driving force for the gelation includes hydrogen bonding and π-π stacking. Evaluated by UV-spectroscopy, the gel showed a prompt initial response to glucose at low concentration of 0.012 mmol/mL, which is a critical concentration of venous plasma glucose for diabetes. Significantly, this organogel exhibits excellent sensitivity to glucose among seven sugars tested (i.e., mannitol, galactose, lactose, maltose, sucrose, and fructose). The proposed formation of hydrogen-bonded complexes during the glucose sensing was supported by our energy calculation. Meanwhile, this organogel exhibits pH-response. Importantly, this LMOG could be conveniently recycled and thus be reused.
Mucin 1 (MUC1), a transmembrane protein, is closely associated with the malignancy and metastasis of canine mammary tumors; however, the role of overexpressed MUC1 in the development of cancer cells and response to drug treatment remains unclear. To address this question, we developed a new canine mammary tumor cell line, CIPp-MUC1, with an elevated expression level of MUC1. In vitro studies showed that CIPp-MUC1 cells are superior in proliferation and migration than wild-type control, which was associated with the upregulation of PI3K, p-Akt, mTOR, Bcl-2. In addition, overexpression of MUC1 in CIPp-MUC1 cells inhibited the suppressing activity of disulfiram on the growth and metastasis of tumor cells, as well as inhibiting the pro-apoptotic effect of disulfiram. In vivo studies, on the other side, showed more rapid tumor growth and stronger resistance to disulfiram treatment in CIPp-MUC1 xenograft mice than in wild-type control. In conclusion, our study demonstrated the importance of MUC1 in affecting the therapeutical efficiency of disulfiram against canine mammary tumors, indicating that the expression level of MUC1 should be considered for clinical use of disulfiram or other drugs targeting PI3K/Akt pathway.
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