Isoindole derivatives R 0140Microwave-Promoted Beller Synthesis of N-Substituted 2,3,3a,4,7,7a-Hexahydroisoindole-1,3-diones. -The conditions recently developed by Beller and coworkers are modified by application of microwave irradiation instead of conventional heating. The three-component reaction of an amide (benz-or acetamide), an α,β-unsaturated aldehyde, and an N-substituted maleimide under optimized conditions provides the isoindole derivatives in good to excellent yields in a short reaction time. -(DA, C.-X.; SHOU, W.-G.; WANG*, Y.-G.; Chin.
A rapid and facile synthesis of N-substituted 2,3,3a,4,7,7a-hexahydroisoindole-1,3-dione derivatives via microwave-promoted Beller three-component domino reaction of α,β-unsaturated aldehydes, amides and N-substituted maleimides was described.
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