Abstract:Isoindole derivatives R 0140Microwave-Promoted Beller Synthesis of N-Substituted 2,3,3a,4,7,7a-Hexahydroisoindole-1,3-diones. -The conditions recently developed by Beller and coworkers are modified by application of microwave irradiation instead of conventional heating. The three-component reaction of an amide (benz-or acetamide), an α,β-unsaturated aldehyde, and an N-substituted maleimide under optimized conditions provides the isoindole derivatives in good to excellent yields in a short reaction time. -(DA, … Show more
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