Material extracted from hyphae ofFusarium avenaceum, isolated from foliage of balsam fir,Abies balsamea, was toxic to spruce budworm larvae when incorporated into insect diet. The major insecticidal component of the toxic fraction was identified by chemical and spectroscopic methods as enniatin complex, rich in enniatin A/A1. Possible ecological implications of these observations are considered.
Specific and selective protease inhibitors are potentially powerful tools in clinical therapy. These inhibitors could be used to inactivate the target proteases in the pathogenic processes of human diseases such as emphysema, arthritis, pancreatitis, thrombosis, high blood pressure, muscular dystrophy, cancers, AIDS, and many others1~3). During our screening for biologically active compounds from marine sources, a strain of the fungus Microascus longirostris was found to produce secondary metabolites that strongly inhibited cysteine proteases. Bioassay-guided fractionation of the methanolic extract
Abstract:Two new metabolites (1 and 2) were isolated from the marine fungus Microsphaeropsis olivacea. The structures were elucidated, through analysis of the spectroscopic data, as an unusual methyl-branched unsaturated fatty acid, 10-methyl-9Z-octadecenoic acid (I), and the glyceride (2). The locations of the double bond and the methyl branching were determined from the electron impact (EI) mass spectrum of the picolinyl derivative of 1 and from MSIMS data on the hydrogenation products of 1 and 2.Key words: Microsphaeropsis olivctcea, marine fungus, methyl-branched unsaturated fatty acid, picolinyl ester.RCsumC : On a is016 deux nouveaux metabolites (1 et 2) i partir du champignon marin Microsphaet-opsis olivacea. Faisant appel 2 des donnCes spectroscopiques, on a Ctabli que les structures sont associCes i un acide gras insaturt portant un mCthyle comme chaine latCrale, I'acide 10-mCthyloctadCc-9Z-kno'ique (1) et de son glycCride (2). Les positions des doubles liaisons et de la ramification mCthyle ont CtC dCterminCes par spectromCtrie de masse par impact Clectronique sur le derive pinacolyle du composC 1 et par des donnCes de SMISM sur les produits d'hydrogknation des composCs 1 et 2.Mots clis : Microsphaeropsis olivacea, champignons marins, acide gras insaturC portant une ramification mCthyle.[Traduit par la rCdaction]
Floridicin 1, a diterpene containing a [4.3.1] bicyclic ring system, has been isolated from the soft coral Xenia florida, and represents a new class of tricarbocyclic diterpenes.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.