The microstructure and the mechanical properties of pure Fe after HPT-straining at a rotation-speed of 0.2 rpm under a compression pressure of 5 GPa were investigated. The elongated grains with 300 nm thick and 600 nm long were observed at r = 1.5 mm away from the disk center regions after HPT-straining for 5 turns ( εeq = 45). The obtained Vickers microhardness in the submicrocrystalline Fe after 5 turns was around Hv 3.6 GPa. The engineering tensile strength and total elongation of the HPT-processed Fe for 10 turns were 1.9 GPa and 30 %. These facts suggest that HPT-straining leads to significant refinement of microstructure and increase in strength with good ductility.
Far lateral lumbar intervertebral disk herniation (FLLIDH) most commonly occurs far lateral to the intervertebral facet at L3-L4 and L4-L5 and accounts for 3.8% of all lumbar disk herniations. Traditional surgery for FLLIDH involves massive surgical trauma, damage to the spinal structure, and instability of the lumbar spine. The goals of this study were to perform a systematic review of the literature and investigate the clinical outcomes of transforaminal percutaneous endoscopic surgery in the treatment of FLLIDH. Between October 2010 and May 2012, fifteen patients diagnosed with FLLIDH underwent transforaminal percutaneous endoscopic surgery at the authors' institution to remove the herniated disk and release the nerve root. Pain was measured pre- and postoperatively with a visual analog pain scale (VAS), and postoperative outcomes were evaluated using MacNab's criteria. A PubMed database search was conducted for the systematic review. Median operative time was 100 minutes (range, 80-140 minutes). Median volume of intraoperative blood loss was 20 mL (range, 10-50 mL). Patients were followed postoperatively for a median of 6 months (range, 1-12 months). MacNab's criteria rated 12 (80.0%) surgical outcomes as excellent, 2 (13.3%) as good, and 1 (6.7%) as fair. The systematic review included 14 studies. Transforaminal percutaneous endoscopic surgery appears to be a safe and effective minimally invasive procedure for treating FLLIDH. However, as demand for this type of surgery increases, the possibility of intraoperative aggravated leg pain and compression injury of the ganglion must be considered.
Purpose. Abnormal methylation of Grainyhead-like 2 (GRHL2) is associated with a substantial role in the malignant phenotype of tumor patients. Our present research is aimed at studying the abnormal expression of GRHL2 and the association of methylation in patients with acute leukemia and its relationship with prognosis. Materials and Methods. We used quantitative real-time polymerase chain reaction (qRT-PCR) for detecting the aberrant expression level of GRHL2 in 60 patients with acute leukemia and 60 normal controls. We analyzed the significant correlation between the expression level of GRHL2 with clinicopathological features and patients’ prognosis in acute leukemia using the corresponding statistical methods. Secondly, we employed qRT-PCR and Western blotting to detect the mRNA and protein levels of GRHL2 in leukemia cell lines. Next, we used methylation-specific polymerase chain reaction (MSP) technology for detecting the methylation of GRHL2 in clinical samples with acute leukemia and cell lines. Then we investigated the demethylating effect of arsenic trioxide and 5-azacitidine on the mRNA and protein expression levels of GRHL2 in cell lines of acute leukemia. Finally, we studied the effects of arsenide trioxide and 5-azacitidine on the proliferation of leukemia cells and the TGF-β signaling pathway. Results. We found a lower level of GRHL2 expression not only in acute leukemia patients but also in cell lines when compared with normal controls. At the same time, the expression level of GRHL2 in patients with acute leukemia was significantly correlated with leukocyte count, platelet count, and cytogenetic risk grouping. In addition, the lower GRHL2 expression group showed a significantly lower overall survival rate in acute leukemia patients than that of patients with a higher GRHL2 expression group. Univariate and multivariate analyses revealed that the expression of GRHL2 is an independent risk factor in acute leukemia patients. The methylation level of the GRHL2 promoter region in acute leukemia patients and cell lines was significantly higher than the normal control group, and we found the elevated mRNA and protein levels of GRHL2 in acute leukemia cell lines after the use of the demethylation drug arsenic trioxide and 5-azacitidine. At the same time, arsenide trioxide and 5-azacitidine are associated with the inhibition of cellular proliferation of acute leukemia cells and also promote the elevated expression of TGF-β signaling pathway-linked proteins, including TGF-β, Smad2, Smad3, and Smad4. Conclusion. Increased expression and methylation level of GRHL2 are closely associated with the prognosis and malignant phenotype of acute leukemia patients and play an irreplaceable role in the occurrence and development of patients with acute leukemia.
We numerically demonstrate that an electromagnetically induced transparency (EIT) effect can be achieved in an all-dielectric metamaterial, whose micro unit consists of two cylindrical throughhole cubes (CTCs). Two CTCs produce electric and magnetic Mie resonances in the vicinity of 6.2 GHz, respectively. Specially, the appropriate control on the interaction between two Mie resonances can lead to destructive interference of scattering fields, and thus the EIT effect with low loss and high transmission can be achieved. The influences of key parameters of all-dielectric metamaterial on its EIT effects are also investigated. In addition, the slow wave property of proposed structure is verified by computing the group delay, and the superiority of CTC is discussed. Such an all-dielectric metamaterial may have potential applications in areas such as low loss slow wave devices and high sensitivity sensors.
The magnetic separation system is an important part of the automatic testing equipment. There are two methods to magnetize, internal magnetic attracting and external magnetic attracting. We compare the difference of the realization methods and the magnetic field distribution of the two ways. Then we select appropriate method to magnetize.
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