A series of aliphatic polyester dendrons, generations 1 through 8, were prepared with a core p-toluenesulfonyl ethyl (TSe) ester as an easily removable protecting group that can be efficiently replaced with a variety of nucleophiles. Using amidation chemistry, a tridentate bis(pyridyl)amine ligand which is known to form stable complexes with both Tc(I) and Re(I) was introduced at the dendrimer core. Metalation of the core ligand with (99m)Tc was accomplished for generations 5 through 7, and resulted in regioselective radiolabeling of the dendrimers. The distribution of the radiolabeled dendrimers was evaluated in healthy adult Copenhagen rats using dynamic small-animal single photon emission computed tomography (SPECT). The labeled dendrimers were cleanly and rapidly eliminated from the bloodstream via the kidneys with negligible nonspecific binding to organs or tissues being observed. These data were corroborated by a quantitative biodistribution study on the generation 7 dendrimer following necropsy. The quantitative biodistribution results were in excellent agreement with the data obtained from the dynamic SPECT images.

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Les auteurs, après avoir expliqué ce que c'est que de souffrir d'une dépression et les conséquences impliquées, font ensuite une critique de l'institution psychiatrique. Ils décrivent leur projet : Solidarité-psychiatrie inspiré par l'expérience de D. W. Winnicott et le concept d'institution de M. Mannoni. Le but du projet est de fournir un lieu de rencontre pour les gens concernés par la réalité de la maladie mentale où ils refléteraient les différents aspects de la maladie mentale et apprendraient à lire ses manifestations dans la vie quotidienne. Le projet est devenu opérationnel en avril 1979, depuis lors plus de 100 personnes en ont bénéficié. Elles ont des rencontres hebdomadaires, des activités continues comme le jeu théâtral, des discussions régulières sur des thèmes variés ; trois comités ont été formés : 1) un comité pour l'atelier théâtre ; 2) un comité pour la réflexion ; 3) un comité pour faire face aux urgences. Elles ont aussi travaillé sur les procédures nécessaires pour obtenir une charte.The authors, after explaining what it is to suffer a depression and the consequences involved, then follow with a criticism of the psychiatric institution. They describe their project : «Solidarité-Psychiatrie» inspired by D. W. Winnicott's experience and M. Mannoni's concept of institution. The aim of this project is to provide a meeting place for people concerned with the reality of mental illness where they would reflect on different aspects of mental illness and learn how to read to its manifestations in everyday life. The project became operational in April 1979, since then more than 110 persons have benefited from it. They have weekly meetings, ongoing activities such as a theatrical play, regular discussions on various themes; three committees have been formed 1) a committee for a theatrical workshop; 2) a committee of reflexion; 3) a committee to deal with emergencies. They are also working on the procedures necessary for the request of a chart