Reactivity and Selectivity of F2 Toward 3,4,6-Tri-O-acetyl-<scp>D</scp>-Glucal in Anhydrous HF: Synthesis of [18F]2-Fluoro-2-deoxy-β- <scp>D</scp>-allose and Its Use for the Detection of a Breast Tumor

This paper reports the synthesis and characterization of monomers itaconic anhydride (IA) and tri-O-acetyl-D-glucal (TAG) as well as 4,6-di-O-acetyl-D-glucal (PSG). The homopolymers and copolymers of IA and TAG were synthesized via free radical copolymerization in bulk using azobisiso-butyronitrile as an initiator using different feed ratios of monomers. Their structural, molecular, and thermal characterization was done using 1H-NMR spectroscopy, gel permeation chromatography, and differential scanning calorimetry, respectively. The glass transition temperature (Tg) of copolymers was found in the range of 139-145 ?C. The highest Tg was found for IA-TAG2 copolymers, whereas IA-TAG4 copolymer showed lowest Tg. The molecular weight of the copolymers was in the range 5157-5499 g mol-1. The monomer TAG undergoes Ferrier rearrangement in water to give PSG. The antimicrobial activity of IA, TAG, PSG and IA-TAG copolymers was studied using the minimum microbicidal concentration-broth dilution method. TAG, IA, and PSG, as well as homopolymer and copolymers of IA and TAG are excellent antimicrobial agents.

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Antimicrobial and anticancer activities of copolymers of tri-O-acetyl-D-glucal and itaconic anhydride

Deoghare

Balaji²,

Dhandapani

et al. 2022

J Serb Chem Soc

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Reactivity and Selectivity of F₂ Toward 3,4,6-Tri-O-acetyl-D-Glucal in Anhydrous HF: Synthesis of [¹⁸F]2-Fluoro-2-deoxy-β- D-allose and Its Use for the Detection of a Breast Tumor

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Antimicrobial and anticancer activities of copolymers of tri-O-acetyl-D-glucal and itaconic anhydride

Antimicrobial and anticancer activities of copolymers of tri-O-acetyl-D-glucal and itaconic anhydride

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Reactivity and Selectivity of F2 Toward 3,4,6-Tri-O-acetyl-D-Glucal in Anhydrous HF: Synthesis of [18F]2-Fluoro-2-deoxy-β- D-allose and Its Use for the Detection of a Breast Tumor

Cited by 1 publication

References 0 publications

Antimicrobial and anticancer activities of copolymers of tri-O-acetyl-D-glucal and itaconic anhydride

Antimicrobial and anticancer activities of copolymers of tri-O-acetyl-D-glucal and itaconic anhydride

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Product

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Reactivity and Selectivity of F₂ Toward 3,4,6-Tri-O-acetyl-D-Glucal in Anhydrous HF: Synthesis of [¹⁸F]2-Fluoro-2-deoxy-β- D-allose and Its Use for the Detection of a Breast Tumor