In this paper we focus on the studies of graphene wrinkling, from its formation to collapse, and its dependence on aspect ratio and temperature using molecule dynamics simulation. Based on our results, the first wrinkle is not formed on the edge but in the interior of graphene. The fluctuations of edge slack warps drive the wrinkling evolution in graphene which is distinguished from the bifurcation in continuum film. There are several obvious stages in wrinkling progress, including incubation, infancy, youth, maturity and gerontism periods which are identified by the atomic displacement difference due to the occurrences of new wrinkles. The wrinkling progress is over when the C-C bonds in highly stretched corners are broken which contributes to the wrinkling collapse. The critical wrinkling strain, the wrinkling pattern and extent depend on the aspect ratio of graphene, the wrinkling level and collapsed strains do not. Only the collapsed strain is sensitive to the temperature, the other wrinkling parameters are independent of the temperature. Our results would benefit the understanding of the physics of graphene wrinkling and the design of nanomechanical devices by tuning the wrinkles.

These results suggested that plasma miRNAs could be potential specific biomarker for early detection COPD.

In a previous study, we determined that plasma miRNAs are potential biomarkers for cigarette smoking‐related lung fibrosis. Herein, we determine whether tissue‐specific and plasma miRNA profiles could be promising biomarkers for histological classification and TNM stage in non‐small cell lung cancer (NSCLC). Plasma miRNA profiling preoperatively and seven days postoperatively, and cancer and normal tissue miRNA profiling were performed in NSCLC patients and matched healthy controls. There was a > twofold change for all signature miRNAs between the NSCLC patients and controls, with P values of < 0.05. We found that tissue‐specific and plasma miR‐211‐3p, miR‐3679‐3p, and miR‐4787‐5p were promising biomarkers of different staging lung squamous cell carcinoma, and miR‐3613‐3p, miR‐3675‐3p, and miR‐5571‐5p were promising biomarkers of different staging lung adenocarcinoma. These results suggest that tissue‐specific and plasma miRNAs could be potential biomarkers of histological classification and TNM stage in NSCLC.

The wrinkling characteristics of a rectangular graphene membrane under local tension are studied in this paper based on the continuum theory. The characteristics of the primary bifurcation and secondary wrinkling are studied to discover the physics of graphene wrinkling. The wrinkling geometry is predicted by a continuum theory model. The results reveal that the first wrinkle is formed at the primary bifurcation point. The non-uniform stretch-induced compressed effects, that originate from both the loaded portion and the clamped edges, buckle the graphene to form the first wrinkle. Secondary wrinkling is generated on the boundary of the wrinkled regions and the slack regions near the loaded portion in the post-wrinkling stage is the intrinsic nature of the wrinkling rupture and evolution of graphene. In addition, the length of the loaded portion and the aspect ratio of graphene have great effects on the wrinkling characteristics. These results are tremendously useful in understanding the intrinsic nature of the structural instability of graphene.

Graphene oxide (GO) is widely used to improve the pore structure, dispersion capacity, adsorption selectivity, resistance to acids and bases, and thermal stability of metal–organic frameworks (MOFs). However, it remains a daunting challenge to enhance selectivity simply by modifying the pore surface polarity and producing a suitable pore structure for CO2 molecules through a combination of GO with MOFs. Herein, we demonstrate a novel porous hyper-cross-linked polyimide–UiO–graphene composite adsorbent for CO2 capture via in situ chemical knitting and condensation reactions. Specifically, a network of polyimides rich in carbonyl and nitrogen atoms with amino terminations was synthesized via the reaction of 4,4′-oxydiphthalic anhydride (ODPA) and 2,4,6-trimethyl-1,3-phenylenediamine (DAM). The product plays a crucial role in the separation of CO2 from N2. As expected, the resulting composite (PI-UiO/GO-1) exhibited a 3-fold higher CO2 capacity (8.24 vs 2.8 mmol·g–1 at 298 K and 30 bar), 4.2 times higher CO2/N2 selectivity (64.71 vs 15.43), and significantly improved acid–base resistance stability compared with those values of pristine UiO-66-NH2. Furthermore, breakthrough experiments verified that the porous composites can effectively separate CO2 from simulated fuel gas (CO2/N2 = 15/85 vol %) with great potential in industrial applications. More importantly, this strategy can be extended to prepare other MOF-based composites. This clearly advances the development of MOF–polymer materials for gas capture.

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Chemotherapy is the standard treatment of in advanced lung adenocarcinoma patients without driver mutation. However, few drugs could be selected when diseases progressed after second-line treatment. As a small molecule inhibitor of vascular endothelial growth factor receptor-2 (VEGFR-2), apatinib was suggested mainly using in advanced gastric cancer. In this study, we showed the results of apatinib as second-line to fourth-line treatment in EGFR wild-type advanced lung adenocarcinoma patients. 16 EGFR wild-type advanced lung adenocarcinoma patients were administrated apatinib (250-500 mg/d) orally. 3 patients showed partial response and 8 patients showed stable diseases response to apatinib, with a medium progression-free survival (PFS) of 4.4 month (2-10 months). The objective remission rate (ORR) was 18.75%(3/16). The total disease control rate (DCR) was 68.75% (11/16). The main toxicities were hypertension, hand-foot syndrome, proteinuria and thrombocytopenia which were tolerable and manageable. So, apatinib might be an optional choice for post-first-line treatment of EGFR wild-type advanced lung adenocarcinoma patients.

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