Plasma mi<scp>RNAs</scp> might be promising biomarkers of chronic obstructive pulmonary disease

Wang, Maoyun; Huang, Yu‐Chuan; Liang, Zongan; Liu, Dan; Liu, Yanrong; Dai, Yong; Guanglin, Feng; Wang, Changguo

doi:10.1111/crj.12194

Cited by 48 publications

(36 citation statements)

References 37 publications

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“…(45) A recent report found that miR-145-5p is upregulated in plasma from asthma patients. (46) Thus, since recent reports suggest an increase in respiratory problems with personnel deployed to areas with open air burn pits (20) , one mechanism may include induction of miR-145-5p levels which can alter inflammatory gene responses and promote onset of respiratory diseases such as asthma. Likewise, miR-17-5p has been shown to be upregulated in various disease states including: pulmonary artery hypertension, hepatocellular carcinoma and lung cancer.…”

Section: Discussionmentioning

confidence: 99%

MicroRNAs as Novel Biomarkers of Deployment Status and Exposure to Polychlorinated Dibenzo-p-Dioxins/Dibenzofurans

Woeller

Thatcher

Twisk

et al. 2016

Journal of Occupational &Amp; Environmental Medicine

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Objective To determine if service members deployed to locations with open air burn pits have different serum microRNA (miRNA) profiles after deployment compared to length-of-service matched, non-deployed individuals. We also tested for correlations between miRNA and serum levels of Polychlorinated Dibenzo-p-Dioxins/Dibenzofurans (PCDD/PCDFs). Methods MiRNAs were isolated and quantified by PCR array. Groups were analyzed for differences in miRNA expression. Correlation between serum miRNA and PCDD/PCDFs were assessed with a linear regression model. Results Several miRNAs were differentially expressed after deployment and a partially overlapping set of miRNAs were identified between deployed and non-deployed individuals. Significant correlations between miRNAs and PCDD/PCDFs were identified. Conclusions Serum miRNA levels show a link between deployment to locations with open burn pits and environmental exposures that can take place during deployment.

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Section: Discussionmentioning

confidence: 99%

MicroRNAs as Novel Biomarkers of Deployment Status and Exposure to Polychlorinated Dibenzo-p-Dioxins/Dibenzofurans

Woeller

Thatcher

Twisk

et al. 2016

Journal of Occupational &Amp; Environmental Medicine

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“…Se ha evidenciado que los miR pueden expresarse de forma específica, ya sea por su presencia en un tejido o por aumento de su expresión en sangre periférica u otros fluidos corporales. De esta manera, los miR son secretados como microvesiculas hacia la circulación y por su gran estabilidad en tejidos y fluidos corporales, tienen potencial importante como marcadores diagnósticos (17) .…”

Section: Mecanismo De Acción Micro Arn (Mir)unclassified

“…Sin embargo, cabe señalar que los principales miR presentes en EPOC van a estar asociados a genes que regulan la inflamación, ya que es su mecanismo fisiopatológico principal (17,32) . En…”

Section: Micro Arn Y Epocunclassified

“…La identificación del miR-362-3p y miR-338-3p se considera un potencial marcador importante para diagnóstico de EPOC dado permite diferenciar esta enfermedad de otra patología con componente inflamatorio como el asma bronquial (17) .…”

Section: Micro Arn Y Epocunclassified

“…La inhibición del miR-145, involucrado en la respuesta de reclutamiento de eosinófilos, disminuye la producción de citoquinas IL-13 e IL-5, asociando un alivio importante en la sintomatología inflamatoria en asma bronquial (17) . Sin embargo, la modulación de los miR en EPOC no cuenta aún con estudios clínicos que demuestren la efectividad de esta intervención (15) .…”

Section: Micro Arn Y Epocunclassified

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TEMA 7-2015: Micro ARN y Enfermedad pulmonar obstructiva crónica

Zamora

Garzona²

2015

RC_UCR-HSJD

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Airway smooth muscle inflammation is regulated by microRNA‐145 in COPD

et al. 2016

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Chronic obstructive pulmonary disease (COPD) is a common, highly debilitating disease of the airways, primarily caused by smoking. Chronic inflammation and structural remodelling are key pathological features of this disease, in part caused by the aberrant function of airway smooth muscle (ASM) cells under the regulation of transforming growth factor (TGF)‐β. miRNA are short, noncoding gene transcripts involved in the negative regulation of specific target genes, through their interactions with mRNA. Previous studies have proposed that mRNA‐145 (miR‐145) may interact with SMAD3, an important downstream signalling molecule of the TGF‐β pathway. TGF‐β was used to stimulate primary human ASM cells isolated from healthy nonsmokers, healthy smokers and COPD patients. This resulted in a TGF‐β‐dependent increase in CXCL8 and IL‐6 release, most notably in the cells from COPD patients. TGF‐β stimulation increased SMAD3 expression, only in cells from COPD patients, with a concurrent increased miR‐145 expression. Regulation of miR‐145 was found to be negatively controlled by pathways involving the MAP kinases, MEK‐1/2 and p38 MAPK. Subsequent, overexpression of miR‐145 (using synthetic mimics) in ASM cells from patients with COPD suppressed IL‐6 and CXCL8 release, to levels comparable to the nonsmoker controls. Therefore, this study suggests that miR‐145 negatively regulates pro‐inflammatory cytokine release from ASM cells in COPD by targeting SMAD3.

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Plasma miRNAs might be promising biomarkers of chronic obstructive pulmonary disease

Abstract: These results suggested that plasma miRNAs could be potential specific biomarker for early detection COPD.

Cited by 48 publications

References 37 publications

MicroRNAs as Novel Biomarkers of Deployment Status and Exposure to Polychlorinated Dibenzo-p-Dioxins/Dibenzofurans

MicroRNAs as Novel Biomarkers of Deployment Status and Exposure to Polychlorinated Dibenzo-p-Dioxins/Dibenzofurans

TEMA 7-2015: Micro ARN y Enfermedad pulmonar obstructiva crónica

Airway smooth muscle inflammation is regulated by microRNA‐145 in COPD

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