The decreased fmERGs indicate that macular function is impaired in eyes with ERM. The decrease of the b-wave and OPs in the 29 eyes examined after vitrectomy may be due to the still thickened macular retina.
Although the macular volume and length of the IS/OS line correlated weakly with the amplitude of the fmERGs, a preserved macular morphology does not necessarily guarantee normal-amplitude fmERGs in patients with RP.
ABSTRACT.Purpose: To compare the amplitudes and implicit times of the flicker electroretinograms before and after an intravitreal injection of ranibizumab (IVR) in eyes with a central retinal vein occlusion (CRVO). Methods: We reviewed the medical records of 15 consecutive patients who had macular oedema secondary to CRVO and had received an IVR at the Nagoya University Hospital from November 2013 to July 2014. Flicker ERGs were recorded with both the RETeval TM system and a conventional ERG system before the IVR. One month after the IVR, recordings were repeated with only the RETeval TM system. Results: The mean implicit times of the flicker ERGs of the affected eyes recorded with the RETeval TM system were significantly longer than that of the fellow eyes (32.2 AE 2.6 msec versus 28.1 AE 1.2 msec, p < 0.001). One month after the IVR, the implicit times of the flicker ERGs of affected eyes were significantly shortened from 32.2 AE 2.6 to 30.6 AE 2.2 msec (p < 0.001). Conclusions: The shortening of the implicit times of the flicker ERGs after the IVR indicates an improvement of retinal function after anti-VEGF therapy for CRVO eyes.
A disparity in the time course and degree of recovery of the foveal thickness and macular retinal function was found in eyes with DME after vitrectomy. Part of the functional recovery could be attributed to decreased retinal thickness and the absorption of the subretinal fluid.
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