Changes in Focal Macular ERGs after Macular Translocation Surgery with 360° Retinotomy

Terasaki, Hiroko; Ishikawa, Kohei; Niwa, Yoshio; Piao, Chang-Hua; Niwa, Takashi; Kondo, Mineo; Ito, Yasuki; Miyake, Yoichi

doi:10.1167/iovs.03-0187

Cited by 35 publications

(39 citation statements)

References 18 publications

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“…9,11,12,[15][16][17][18][19][20] Our findings are consistent with these reports, and our Eye results for the 35 AMD eyes showed that the mean BCVA improved from 1.128 ± 0.075 to 0.724 ± 0.049 logMAR units at 12 months and did not worsen at the final examination even after follow-up periods of Z5 years.…”

Section: Discussionsupporting

confidence: 92%

“…The silicone oil was removed after several months, and an intraocular lens was implanted in patients who requested the implantation. [18][19][20] The data are presented as the means ± SEMs. Wilcoxon signed-rank t-tests with the Bonferonni correction were used to compare the BCVA and area of the visual VF before, 12 months after surgery, and at the final examination.…”

Section: Surgical Techniquesmentioning

confidence: 99%

“…Most studies have reported favourable outcomes but for follow-up periods of r2 years after the surgery. 9,11,12,[15][16][17][18][19][20] On the other hand, there are two reports on the visual outcome of macular translocation surgery with follow-up periods of Z3 years, 21,22 and the visual outcomes were reported to be poor in both. However, in these two reports, the visual improvement was not attained even in the first year.…”

Section: Introductionmentioning

confidence: 99%

“…22 We have recorded focal electroretinograms from the translocated macular area and found it was significantly better than that before operation at 22 months postoperatively. 18,20 However, the results after longer follow-up periods have not been reported.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Visual function 5 years or more after macular translocation surgery for myopic choroidal neovascularisation and age-related macular degeneration

Takeuchi

Kachi

Iwata

et al. 2011

Eye

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Section: Discussionsupporting

confidence: 92%

Section: Surgical Techniquesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Visual function 5 years or more after macular translocation surgery for myopic choroidal neovascularisation and age-related macular degeneration

Takeuchi

Kachi

Iwata

et al. 2011

Eye

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“…22 The attenuation of retinal func- 23 and in patients. 24,25 Whether subretinal delivery of a vector results in additional adverse effects will require evaluation in further studies. Modifications of the surgical techniques or the coadminstration of neuroprotective agents may protect the retina against detachment-induced functional attenuation.…”

Section: Discussionmentioning

confidence: 99%

Stable rAAV-mediated transduction of rod and cone photoreceptors in the canine retina

et al. 2003

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Recombinant adeno-associated virus (rAAV) vectors are attractive candidates for the treatment of inherited and acquired retinal disease. Although rAAV vectors are well characterized in rodent models, a prerequisite to their clinical application in human patients is the thorough evaluation of their efficacy and safety in intermediate animal models. In this study, we describe rAAV-2-mediated expression of GFP reporter gene in retinal cells following local vector delivery in dogs. Subretinal delivery of rAAV.CMV.GFP was performed unilaterally in eight normal dogs from 6 weeks of age. The area of retinal transduction was maximized by the optimization of surgical techniques for subretinal vector delivery by pars-plana vitrectomy and the use of fine-gauge subretinal cannulae to create multiple retinotomies. rAAV-2 vectors mediated efficient stable reporter gene expression in photoreceptors and retinal pigment epithelial cells. We found efficient transduction of cone photoreceptors in addition to rods in both the canine retina and after subretinal vector delivery in another intermediate animal model, the feline retina. GFP expression in dogs was confined to the area of the retinal bleb and was sustained in cells at this site for at least 18 months. Electroretinography demonstrated a modest reduction in global rod-mediated retinal function following subretinal delivery of rAAV.CMV.GFP. Three of the eight animals developed delayed-onset intraocular inflammation, in two cases associated with a serum antibody response to GFP protein. We conclude that rAAV-2 vectors mediate efficient sustained transgene expression in rod and cone photoreceptors following subretinal delivery in this intermediate animal model. The possibility of adverse effects including intraocular immune responses and reduced retinal function requires further investigation prior to clinical applications in patients.

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Evaluation of the inner retinal layers following traditional and modified ILM peeling surgery using automatic CMDS quantification algorithm

Shen,

Ye,

et al. 2023

VIEW

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Idiopathic macular hole (IMH) is a vitreoretinal disease that causes severe visual impairment, and the pars plana vitrectomy (PPV) combined with internal limiting membrane peeling (ILMP) is the traditional treatment for IMH. Since the dissociated optical nerve fiber layer (DONFL) is observed in the eyes after the surgery, a modified surgery is put forward to minimize the injury. However, the extent to which the modified surgery reduced damage is not clear. A novel automated image processing system was developed in this study to quantify the damage after the surgery, revealing how the modified surgery reduced the DONFL. Optical coherence tomography (OCT) images and visual acuity were collected from 65 eyes that underwent a vitrectomy with traditional and modified ILM peeling procedure at Zhejiang Provincial People’s Hospital preoperatively. We found that DONFL occurred in all 65 eyes of both the traditional and modified ILM peeling groups. The concentric macular dark spots (CMDS) were automatically measured by the image processing system. The mean total area of CMDS was smaller in the modified ILM peeling group (0.224 ± 0.110 mm2) than that of the traditional ILM peeling group (0.385 ± 0.237 mm2), and there is a significant difference between the two groups (p < .05). The morphological difference in the temporal quadrant of CMDS between the two surgery technology groups was significant (p < .001). This study will provide a clinical research basis for the improvement of macular hole surgery.

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Changes in Focal Macular ERGs after Macular Translocation Surgery with 360° Retinotomy

Abstract: These results indicate that macular function is partially recoverable after macular translocation in some patients.

Cited by 35 publications

References 18 publications

Visual function 5 years or more after macular translocation surgery for myopic choroidal neovascularisation and age-related macular degeneration

Visual function 5 years or more after macular translocation surgery for myopic choroidal neovascularisation and age-related macular degeneration

Stable rAAV-mediated transduction of rod and cone photoreceptors in the canine retina

Evaluation of the inner retinal layers following traditional and modified ILM peeling surgery using automatic CMDS quantification algorithm

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