The demand to discover every single cellular component has been continuously increasing along with the development of biological techniques. The bottom‐up approach to construct a cell‐mimicking system from well‐defined and tunable compositions is accelerating, with the ultimate goal of comprehending a biological cell. From among the available techniques, the artificial cell has been increasingly recognized as one of the most powerful tools for building a cell‐like system from scratch. This review summarizes the development of artificial cells, from a pure giant unilamellar vesicle (GUV) to a controllable, self‐fueled proteoliposome, both of which are highly compartmentalized. The basic components of an artificial cell, as well as the optimal conditions required for successful, reproducible GUV formation and protein reconstitution, are discussed. Most importantly, progress in studying the metabolic reactions in and the motility of a reconstituted artificial cell are the main focus of the review. The ability to perform a complicated reaction cascade in a controllable manner is highlighted as a promising perspective to obtaining an autonomous and movable GUV.

Building a cell de novo, by assembling the core biological elements in a cell‐like space step by step, and mimicking the structure and functions of a living cell has been a long‐standing goal to scientifically understand the mystery of life. In article number 1907182, Kwanwoo Shin and co‐workers introduce the recent advances in the bottom‐up approach to building cell‐mimicking systems, implementing metabolic reactions and motility in artificial cells.

We describe D =8, N = 1 supergravity with an SUi4/1) superalgebra which is a supersymmetric version of SO(6)sUi I). Possible supermultiplets agree with typical representations of SU(4/1). Furthermore Ui1) supercharges are automatically determined by just demanding that the representation is real. Dimensional reductions to the D =7, N = 2 and D = 6 . N = 2 theories are described by using branching rules of SUi4/1).