Sacral tumors are rare. Appropriate surgical resection is crucial to treat the disease while minimizing disease recurrence. We present the results of 93 patients with sacral tumors to analyze the long-term functional and oncological results of patients undergoing en bloc resection. The medical data between January 2003 and July 2010 was retrospectively reviewed. None of the 93 patients died intra- or postoperatively. Patients undergoing intralesional curettage (range, 6500-25,000 mL; mean, 13,500 mL) lost more blood than those patients with wide excision (range, 1000-8100 mL; mean, 3590 mL). Mean follow-up duration from the time of surgery until most recent clinic visit or death was 44.5 months (range, 6-105 months). This study is an educational tool regarding primary sacral tumors and provides evidence on the treatment. It presents results from a large group of patients with sacral tumor. After follow-up, we did not find that sacrificed nerve roots and surgical margins have an impact on the recurrence of the tumor. Patients undergoing intralesional curettage lost more blood than those patients with wide excision. Postoperative bladder/bowel dysfunction was more severe for patients with removal of S1 and S2.
Background: As an important part of m6A modification, FTO plays a carcinogenic effect in cancer. In this study, we aim to explore whether FTO could be a new target for diagnosis and prognostic of patients with liver cancer.Material and Methods: We obtained and analysis data from TCGA database by using R software (version 3.5.1). The box plot was used to analyze the pattern of FTO expression. Receiver operating characteristic (ROC) curve was performed to evaluate diagnostic value of FTO expression in liver cancer. Fisher’s exact and chi-square tests were used to analyze relationship between FTO expression and clinical pathological characteristics. Kaplan-Meier curve and Cox regression analysis were used to explore the prognostic value of FTO in liver cancer.Results: We observed that FTO was down-regulated in liver cancer and was associated with patients’ age. ROC curve showed that FTO expression had good clinical diagnostic value. Our results also revealed that FTO expression was associated with age, histologic grade, M classification, vital status, and overall survival (OS) of patients. Low FTO expression decreased OS, and was an independent predictor of poor prognosis in patients with liver cancer.Conclusion: FTO could serves as a potential biomarker for the diagnosis and prognosis of liver cancer
Castleman disease (CD) rarely presents with obstructive jaundice, which poses a diagnostic and therapeutic challenge to the management of the disease. A 40-year-old man was referred to our hospital for emergent management of upper abdominal pain. An abdominal mass was removed, and the postoperative pathology showed retroperitoneum CD, which was subsequently managed by adjuvant therapy of combination chemotherapy and steroids. One month later, a biliary metal stent was placed due to the presentation of obstructive jaundice. After ~3 months, the patient experienced another episode of obstructive jaundice, and SpyGlass DS cholangioscopy was performed via the biliary tract for biopsy, which pathologically showed biliary malignancies. Radiofrequency ablation was performed with a probe, and another uncovered metal stent was placed within the existing metal stent. No stent occlusion occurred during a 6-month follow-up period. In conclusion, CD rarely presents with obstructive jaundice, and a combination of radiofrequency ablation with metal stent implantation under cholangioscopy can prolong the stent patency time and the survival time of patients.
Background: As an important part of m6A modification, FTO plays a carcinogenic effect in cancer. In this study, we aim to explore whether FTO could be a new target for diagnosis and prognostic of patients with liver cancer.Material and Methods: We obtained and analysis data from TCGA database by using R software (version 3.5.1). The box plot was used to analyze the pattern of FTO expression. Receiver operating characteristic (ROC) curve was performed to evaluate diagnostic value of FTO expression in liver cancer. Fisher’s exact and chi-square tests were used to analyze relationship between FTO expression and clinical pathological characteristics. Kaplan-Meier curve and Cox regression analysis were used to explore the prognostic value of FTO in liver cancer.Results: We observed that FTO was down-regulated in liver cancer and was associated with patients’ age. ROC curve showed that FTO expression had good clinical diagnostic value. Our results also revealed that FTO expression was associated with age, histologic grade, M classification, vital status, and overall survival (OS) of patients. Low FTO expression decreased OS, and was an independent predictor of poor prognosis in patients with liver cancer.Conclusion: FTO could serves as a potential biomarker for the diagnosis and prognosis of liver cancer
BackgroundLiver transplantation has made significant progress in recent decades. Lung cancer is one of the most frequently occurring cancers after liver transplantation. However, the risk of lung cancer among liver transplant patients compared with the general population is unclear. The aim of this meta‐analysis was to assess the risk of developing lung cancer after liver transplantation.MethodsAll eligible studies published in PubMed, Web of Science, and Embase from database inception to April 2022 were included. Standardized incidence ratio was used to describe the increased risk of lung cancer in liver transplant recipients as compared with the general population. The random‐effects model was used for the calculations. A funnel plot and Egger test were performed to assess the potential publication bias.ResultsOur meta‐analysis included 15 studies, which involved 76,897 liver transplantation patients. Studies included in this review showed significant heterogeneity (I2 = 65.3%; p < 0.001), which required a random‐effects model for effect pooling. The results indicated a significant higher risk of developing lung cancer in liver transplant patients than the general population with a pooled SIR of 2.06 (95% CI: 1.73, 2.46, p < 0.001). When stratified by region, no significant regional difference was observed. It showed a similarly doubled risk of lung cancer in Europe and North America, but an insignificantly increased risk in Asian populations. The sensitivity analysis by removal and substitution of each literature did not change the results.ConclusionOur meta‐analysis suggests that liver transplant patients are twice as likely as the general population to develop lung cancer. Further research on risk factors for the development of lung cancer after liver transplantation should be conducted and appropriate surveillance protocols should be developed to reduce the risk of its occurrence.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.