Atrichia congenita is a rare genodermatoses is characterized by a mutation of the human hairless (HR) gene on chromosome 8p22. There is loss of scalp hair between one to six months of age, after which no growth occurs. Eyebrow, eyelash, and body hair may also be sparse or absent; patients may have a few pubic and axillary hairs. The condition may present in isolation or along with other defects.
Background:
Androgenetic alopecia (AGA) is characterized by androgen-related progressive thinning of the scalp hair in a defined pattern. It has an effect on social and psychological well-being of the patient. It is often recalcitrant to medical treatment alone.
Aim:
The aim of the study was to compare the efficacy of 5% minoxidil and 5% minoxidil plus platelet-rich plasma (PRP) in same patient for the treatment of AGA.
Materials and Methods:
A prospective randomized study was conducted on 50 patients of AGA attending the outdoor department. Scalp of each patient was divided into right side and left side, to compare the effectiveness of 5% minoxidil on the right side with combination of 5% minoxidil and intradermal PRP on the left side at an interval of 1 month for a period of 6 months. Clinical improvement was assessed monthly till 6 months by the serial hair pull test, global photography, patient satisfaction score, trichoscopic evaluation, and hair density.
Results:
For post-procedure subjective perception at the end of 6 months, the minoxidil 5% side showed good response in 41% (
n
= 18), moderate in 20% (
n
= 9), and poor in 39% (
n
= 17), whereas the PRP + minoxidil 5% side showed good response in 59% (
n
= 26), moderate in 16% (
n
= 7), and poor in 25% (
n
= 11) of the patients.
Conclusion:
The combination consists of 5% minoxidil and intradermal PRP, which appears to be simple, safe, and effective treatment in AGA. It can be used in poor responders in conventional medical therapy.
Article Info
Adverse drug reaction assessmentAn observational cross sectional study was undertaken in the Dermatology out Patients Department (OPD) of Mathura Das Mathur Hospital, Jodhpur, for period of 12 th months. All the patients visiting the Dermatology out Patients (OPD) Department between January2018 to December2018 with any suspected cutaneous adverse drug reaction was included in the study.
Causality assessmentCasualty assessments of the patients were done by two scales 10 :
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