ABSTRACT:In the last two decades, the transdermal drug delivery system (TDDS) has become a emerging technology that offers significant clinical benefits over other dosage forms. Because transdermal drug delivery offers controlled rate of release of the drug, maintain steady state blood concentration, convenient and pain-free self-administration for patients, avoidance of hepatic first-pass metabolism and the GI tract for poorly bioavailable drugs over other routes of delivery. Characterization of transdermal patch is used to evaluate quality, size, time of onset & duration, adhesive property, thickness, weight of patch, moisture of content, uniformity & cutaneous toxicological studies. The present article reviews the types of transdermal patches, selection of drug candidates and polymers suitable to be formulated as transdermal system, advantages, disadvantages of formulation design and the methods of evaluation.
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