Drug Delivery Applications of Chitosan

Jana, Sougata; Sen, Kalyan Kumar; Gandhi, Arijit; Jana, Subrata; Roy, Chandrani

doi:10.4324/9781315313535-12

Cited by 2 publications

(2 citation statements)

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“…Furthermore, the absolute values of ζ-potential increased positively at lower pH values due to Chi amino groups (−NH 2 ), which protonate (−NH 3 + ) in the acidic area below pH 6.3–6.5 (pI of neat Chi). 42 For Chi-77KS/AMOX-coated surfaces, the shift of pI toward more alkaline from pI = 5.2 to pI = 6.5 is visible, which is assumed to be due to the positively charged secondary and primary groups of AMOX in/at formed PESC (p K of secondary amine: 7.5 and primary amine: 9.9, according to potentiometric titration of pure AMOX, see Figure S1A ). A maximum positive ζ-potential and shifting of pI more to the theoretical value of Chi is observed compared to the coating of Chi-77KS.…”

Section: Resultsmentioning

confidence: 96%

Bioactive Functional Nanolayers of Chitosan–Lysine Surfactant with Single- and Mixed-Protein-Repellent and Antibiofilm Properties for Medical Implants

Ajdnik

Zemljič

Plohl

et al. 2021

ACS Appl. Mater. Interfaces

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Medical implant-associated infections resulting from biofilm formation triggered by unspecific protein adsorption are the prevailing cause of implant failure. However, implant surfaces rendered with multifunctional bioactive nanocoatings offer a promising alternative to prevent the initial attachment of bacteria and effectively interrupt biofilm formation. The need to research and develop novel and stable bioactive nanocoatings for medical implants and a comprehensive understanding of their properties in contact with the complex biological environment are crucial. In this study, we developed an aqueous stable and crosslinker-free polyelectrolyte–surfactant complex (PESC) composed of a renewable cationic polysaccharide, chitosan, a lysine-based anionic surfactant (77KS), and an amphoteric antibiotic, amoxicillin, which is widely used to treat a number of infections caused by bacteria. We successfully introduced the PESC as bioactive functional nanolayers on the “model” and “real” polydimethylsiloxane (PDMS) surfaces under dynamic and ambient conditions. Besides their high stability and improved wettability, these uniformly deposited nanolayers (thickness: 44–61 nm) with mixed charges exhibited strong repulsion toward three model blood proteins (serum albumin, fibrinogen, and γ-globulin) and their competitive interactions in the mixture in real-time, as demonstrated using a quartz crystal microbalance with dissipation (QCM-D). The functional nanolayers with a maximum negative zeta potential (ζ: −19 to −30 mV at pH 7.4), water content (1628–1810 ng cm –2 ), and hydration (low viscosity and elastic shear modulus) correlated with the mass, conformation, and interaction nature of proteins. In vitro antimicrobial activity testing under dynamic conditions showed that the charged nanolayers actively inhibited the growth of both Gram-negative ( Escherichia coli ) and Gram-positive ( Staphylococcus aureus ) bacteria compared to unmodified PDMS. Given the ease of fabrication of multifunctional and charged biobased coatings with simultaneous protein-repellent and antimicrobial activities, the limitations of individual approaches could be overcome leading to a better and advanced design of various medical devices (e.g., catheters, prosthetics, and stents).

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Section: Resultsmentioning

confidence: 96%

Bioactive Functional Nanolayers of Chitosan–Lysine Surfactant with Single- and Mixed-Protein-Repellent and Antibiofilm Properties for Medical Implants

Ajdnik

Zemljič

Plohl

et al. 2021

ACS Appl. Mater. Interfaces

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“…Films are widely used as a coating to prolong the shelf life of perishable fruits and vegetables. Polysaccharides have extensive applications in developing edible coatings; one example is using a film made from a blend of bael fruit gum and chitosan to improve film-forming properties (Jana & Jana, 2020). The film containing equal parts chitosan and bael fruit gum showed the lowest swelling index (2.3 ± 0.11).…”

Section: Application Of Polysaccharides In Film Formationmentioning

confidence: 99%

Bioactive polysaccharides from Aegle marmelos fruit: Recent trends on extraction, bio‐techno functionality, and food applications

Sharma,

Bains,

Goksen

et al. 2024

Food Science & Nutrition

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Polysaccharides from non‐conventional sources, such as fruits, have gained significant attention recently. Aegle marmelos (Bael), a non‐conventional fruit, is an excellent source of biologically active components with potential indigenous therapeutic and food applications. Apart from polyphenolic components, this is an excellent source of mucilaginous polysaccharides. Polysaccharides are one the major components of bael fruit, having a high amount of galactose and glucuronic acid, which contributes to its potential therapeutic properties. Therefore, this review emphasizes the conventional and emerging techniques of polysaccharide extraction from bael fruit. Insight into the attributes of polysaccharide components, their techno‐functional properties, characterization of bael fruit polysaccharide, emulsifying properties, binding properties, reduction of hazardous dyes, application of polysaccharides in film formation, application of polysaccharide as a nanocomposite, and biological activities of bael fruit polysaccharides are discussed. This review also systematically overviews the relationship between extraction techniques, structural characteristics, and biological activities. Additionally, recommendations, future perspectives, and new valuable insight towards better utilization of bael fruit polysaccharide have been given importance, which can be promoted in the long term.

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Drug Delivery Applications of Chitosan

Cited by 2 publications

References 1 publication

Bioactive Functional Nanolayers of Chitosan–Lysine Surfactant with Single- and Mixed-Protein-Repellent and Antibiofilm Properties for Medical Implants

Bioactive Functional Nanolayers of Chitosan–Lysine Surfactant with Single- and Mixed-Protein-Repellent and Antibiofilm Properties for Medical Implants

Bioactive polysaccharides from Aegle marmelos fruit: Recent trends on extraction, bio‐techno functionality, and food applications

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