A novel strategy for N‐chlorosuccinimide mediated direct sulfenylation of 1‐aryl pyrazolones using aryl thiols has been developed at room temperature. The protocol was found to be simple, efficient and transition metal‐free to afford the target products in good to excellent yields without further purification. The prepared compounds were characterised by 1H NMR, 13C NMR and IR spectroscopy. The skeleton of one of the synthesized compounds has been well confirmed by X‐ray single crystal diffraction (XRD) analysis as well as ORTEP diagram.
The analogs of nitrogen-based heterocycles occupy an exclusive position as a value of more than 75%
of drugs approved by the FDA and currently available in the market are nitrogen-containing heterocyclic
moieties. Among many N-containing heterocycles, quinolines have become important due to their
variety of applications in medicinal, synthetic organic chemistry as well as in the field of industrial
chemistry. Present work gives information about the green and clean synthesis using multicomponent
reactions (MCRs) methods and L-proline and ammonium acetate as a catalyst for the synthesis of
quinoline derivatives. Synthesized quinoline derivatives undergo spectroscopic analysis and their
biological evaluation.
In current times, researchers adopted the click chemistry approach for the synthesis of various druglike
molecules by using a few reliable, feasible, practical and selective chemical transformations via
click formation. In present work, we focussed on the most triazole clubbed thiazolidine-2,4-dione
derivatives as the most promising motifs for broad biological application. A total of fifteen (CF-4a-o)
derivatives were synthesized and well characterized with various analytical techniques.
Each of the title dis-symmetric di-Schiff base compounds, C15H12Cl2N2O2 (I) and C14H9BrCl2N2O (II), features a central azo-N—N bond connecting two imine groups, each with an E-configuration. One imine bond in each molecule connects to a 2,6-dichlorobenzene substituent while the other links a 2-hydroxyl-3-methoxy-substituted benzene ring in (I) or a 2-hydroxyl-4-bromo benzene ring in (II). Each molecule features an intramolecular hydroxyl-O—H...N(imine) hydrogen bond. The C—N—N—C torsion angles of −151.0 (3)° for (I) and 177.8 (6)° (II) indicates a significant twist in the former. The common feature of the molecular packing is the formation of supramolecular chains. In (I), the linear chains are aligned along the a-axis direction and the molecules are linked by methoxy-C—H...O(methoxy) and chlorobenzene-C—Cl...π(chlorobenzene) interactions. The chain in (II) is also aligned along the a axis but, has a zigzag topology and is sustained by Br...O [3.132 (4) Å] secondary bonding interactions. In each crystal, the chains pack without directional interactions between them. The non-covalent interactions are delineated in the study of the calculated Hirshfeld surfaces. Dispersion forces make the most significant contributions to the identified intermolecular interactions in each of (I) and (II).
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