Exchange coupled bimagnetic core/shell nanoparticles are promising for emerging multiferroic and spintronic technologies compared with traditional, single-phase materials, as they deliver numerous appealing effects, such as large exchange bias, tailored coercivities, and tunable blocking temperatures. However, it remains a challenge to manipulate their magnetic properties via exchange coupling due to the lack of a straightforward method that enables the general preparation of desired composites. Here we report a robust and general one-pot approach for the synthesis of different kinds of bimagnetic core/shell nanostructures (BMCS NSs). The formation of highly crystalline and monodisperse BMCS NSs adopted a self-adaptive sequential growth, circumventing the employment of complex temperature control and elaborate seeded growth techniques. As a result of large lattice misfit, the presence of interfacial imperfections as an extra source of anisotropy induced diverse exchange coupling interactions in ferro-ferrimagnetic and ferro-antiferromagnetic systems, which had great effects on the improvement of the magnetic properties of BMCS NSs. We envision that this new strategy will open up exciting opportunities toward large-scalable production of such high-quality BMCS NSs, thereby greatly potentiating the prospective applications of nanomagnetic materials.

Over the past decade, noninvasive photothermal therapy (PTT) has been intensively investigated for the treatment of tumors. In contrast to the traditional therapies, PTT has high tumor ablation efficiency and slight or no side effects, which are promising in medicine and clinical applications. In this review, we introduce the application of polymer-based nanomaterials for PTT of cancer and focus on the development profile, typical researches, and the latest research progress of the representative polymer photothermal agents (PTAs). We briefly summarize common PTAs involving inorganic materials and organic small molecules dyes and describe the polymer-based PTAs, including polyaniline (PANI), polypyrrole (PPy), polydopamine (PDA), donor−acceptor (D−A) structured polymer molecules, and poly(3,4ethylenedioxythiophene):poly(4-styrenesulfonate) (PEDOT:PSS).Through this review, we can have an overall understanding of polymer photothermal materials in cancer photothermal therapy.

Micro-/nanomotors are micro-/nanoscale locomotive objects that perform selected mechanical movements upon receiving specific stimuli. Because of this merit, micro-/nanomotors have received great attention in material science [1][2][3] and Micro-/nanomotors are widely used in micro-/nanoprocessing, cargo transportation, and other microscale tasks because of their ability to move independently. Many biological hybrid motors based on bacteria have been developed. Magnetotactic bacteria (MTB) have been employed as motors in biological systems because of their good biocompatibility and magnetotactic motion in magnetic fields. However, the magnetotaxis of MTB is difficult to control due to the lack of effective methods. Herein, a strategy that enables control over the motion of MTB is presented. By depositing synthetic Fe 3 O 4 magnetic nanoparticles on the surface of MTB, semiartificial magnetotactic bacteria (SAMTB) are produced. The overall magnetic properties of SAMTB, including saturation magnetization, residual magnetization, and blocking temperature, are regulated in a multivariate and multilevel fashion, thus regulating the magnetic sensitivity of SAMTB. This strategy provides a feasible method to manoeuvre MTB for applications in complex fluid environments, such as magnetic drug release systems and real-time tracking systems. Furthermore, this concept and methodology provide a paradigm for controlling the mobility of micro-/nanomotors based on natural small organisms. Semiartificial Magnetotactic Bacteria www.advancedsciencenews.com

Supporting information and the ORCID identification number(s) for the author(s) of this articlecan be found under: https://doi.

Interactions of magnetic nanoparticles with cells were investigated from a cell mechanics perspective, and magnetic nanoparticle-based force spectroscopy was developed as a novel method to measure the adhesion force among various cancer cell lines.

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Nanoprobe-based force spectroscopy was developed as a new platform to investigate how substrate stiffness regulates the bacterial adhesion force.

Graphical abstract Abstract Microgravity (MG) effect is a weightlessness phenomenon caused by the distance from the ground or low gravity of other planets outside the earth’s atmosphere. The various effects of MG have been corroborated in human and animal studies and modeled in cell-based analogs. However, the impact of MG on siRNA performance remains to be elucidated, which is crucial for aerospace medicine. In this study, we prepared nucleic acid nanomicelles (EAASc/siRNA) by using tri-block copolymer of PEG45-PAMA40-P(C7A36-DBA37) (EAASc) and siRNA and explored its working mechanism under simulated microgravity (SMG) condition generated by a random positioning machine (RPM). The binding ability of EAASc to siRNA and silence activity were firstly confirmed in normal gravity (NG) environment. Evaluation of PLK1 mRNA expression revealed that gene inhibition efficiencies were increased by 28.7% (HepG2) and 28.9% (A549) under SMG condition, compared with those under NG condition. In addition, mechanism exploration indicated that morphology and migration capability of cancer cells were significantly changed, the internalization of EAASc/siRNA by cells was magnified when the cells were incubated with RPM. No significant difference was observed regarding the expression profiles of genes involved in RNA interference (RNAi) pathway, including Ago2, Dicer, TRBP, and so on. Taken together, siRNA activity was elevated under SMG condition owning to increased cellular internalization. This study, for the first time to our knowledge, provides valuable theory for development and application of siRNA therapeutic in space in the future.