Polymer-Based Nanomaterials for Noninvasive Cancer Photothermal Therapy

Yu, Chanchan; Xu, Lei; Zhang, Yuanyuan; Timashev, Peter; Huang, Yuanyu; Liang, Xing‐Jie

doi:10.1021/acsapm.0c00704

Cited by 60 publications

(35 citation statements)

References 143 publications

(239 reference statements)

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“…Therefore, it is necessary to develop a combined treatment method based on various types of therapeutic treatment, for example, chemotherapy-photodynamic therapy, − photodynamic-photothermal therapy, − chemotherapy-photothermal therapy, − etc. Among them, photothermal therapy is a very promising cancer treatment method due to low invasiveness, small side effects, and high accuracy. − Photothermal therapy generally employs near-infrared lasers to irradiate nanoparticles that reach the tumor site and light is converted to heat to thermally ablate the tumor. There are many types of photothermal agents, such as noble metal nanoparticles, carbon-based materials, organic molecular dyes, etc.…”

Section: Introductionmentioning

confidence: 99%

Enhanced Photothermal Performance by Carbon Dot-Chelated Polydopamine Nanoparticles

Shu

Liu

Chang

et al. 2021

ACS Biomater. Sci. Eng.

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Polydopamine (PDA) has been widely used in biomedical applications including imaging contrast agents, antioxidants, UV protection, and photothermal therapy due to its biocompatibility, metal-ion chelation, free-radical scavenging, and wideband absorption, but its low photothermal efficiency still needs to be improved. In this study, we chelated near-infrared (NIR) sensitive carbon quantum dots on the surface of polydopamine (PDA-PEI@N,S-CQDs) to increase its near-infrared absorption. Surprisingly, although only 4% (w/w) of carbon quantum dots was conjugated on the PDA surface, it still increased the photothermal efficiency by 30%. Moreover, PDA-PEI@N,S-CQDs could also be used as the drug carrier for loading 60% (w/w) of the DOX and achieved stimuli-responsive drug release under lysosomal pH (pH 5.0) and 808 nm laser illumination. For in vitro therapeutic experiment, PDA-PEI@N,S-CQDs showed the remarkable therapeutic performance under 808 nm laser irradiation for killing 90% of cancer cells compared with 50% by pure PDA nanoparticles, and the efficacy was even higher after loading DOX owing to the synergistic effect by photothermal therapy and chemotherapy. This intelligent and effective therapeutic nanosystem based on PDA-PEI@N,S-CQDs showed enhanced photothermal behavior after chelating carbon dots and promoted the future development of a nanoplatform for stimuli-responsive photothermal/chemo therapy.

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Section: Introductionmentioning

confidence: 99%

Enhanced Photothermal Performance by Carbon Dot-Chelated Polydopamine Nanoparticles

Shu

Liu

Chang

et al. 2021

ACS Biomater. Sci. Eng.

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“…PTT utilises light (generally in the 808 nm wavelength) to induce hyperthermia/thermal ablation, and porphyrin PTT agents with low fluorescence quantum yield and singlet oxygen production efficiency can achieve efficient thermal events upon NIR irradiation [ 61 , 62 ]. Improving the intrinsic physical properties of porphyrins for an efficient PTT requires either a shorter excited state lifetime through self-assembly of porphyrin molecules into nanoformulations, or the inclusion of certain metal cations into the porphyrin core [ 63 ].…”

Section: Nano-sized Porphyrin Mofs Cancer Theranostic Modesmentioning

confidence: 99%

Porphyrin NanoMetal-Organic Frameworks as Cancer Theranostic Agents

2022

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Metal-Organic Frameworks (MOFs) are hybrid multifunctional platforms that have found remarkable applications in cancer treatment and diagnostics. Independently, these materials can be employed in cancer treatment as intelligent drug carriers in chemotherapy, photothermal therapy, and photodynamic therapy; conversely, MOFs can further be used as diagnostic tools in fluorescence imaging, magnetic resonance imaging, computed tomography imaging, and photoacoustic imaging. One essential property of these materials is their great ability to fine-tune their composition toward a specific application by way of a judicious choice of the starting building materials (metal nodes and organic ligands). Moreover, many advancements were made concerning the preparation of these materials, including the ability to downsize the crystallites yielding nanoporous porphyrin MOFs (NMOFs) which are of great interest for clinical treatment and diagnostic theranostic tools. The usage of porphyrins as ligands allows a high degree of multifunctionality. Historically these molecules are well known for their reactive oxygen species formation and strong fluorescence characteristics, and both have proved helpful in cancer treatment and diagnostic tools. The anticipation that porphyrins in MOFs could prompt the resulting materials to multifunctional theranostic platforms is a reality nowadays with a series of remarkable and ground-breaking reports available in the literature. This is particularly remarkable in the last five years, when the scientific community witnessed rapid development in porphyrin MOFs theranostic agents through the development of imaging technologies and treatment strategies for cancer. This manuscript reviews the most relevant recent results and achievements in this particular area of interest in MOF chemistry and application.

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“…Abundant NIR‐absorbing nanomaterials, ranging from organic to inorganic nanomaterials, have successfully demonstrated their PAI and/or PTT performance in vivo. [ 39a,b,d,41 ] However, these nonbiodegradable or slowly degradable nanomaterials including Au nanorods, [ 42 ] carbon tubes, [ 43 ] or polymer NPs [ 44 ] will cause potential side effects arising from long‐term residence, which may greatly hinder their translation into clinical applications. In fact, it has been reported that 30–99% of NPs will accumulate in the liver, and long‐term accumulation of NPs has been proved to have negative effects on liver and kidney.…”

Section: Self‐assembling Bile Pigments For Light‐induced Therapeuticsmentioning

confidence: 99%

Self‐assembling bile pigments for cancer diagnosis and therapy

2021

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Nanomaterials that integrate multiple functions provide promising opportunities for noninvasive and targeted cancer diagnosis and therapy. However, the unclear metabolic pathway to nanomaterials brought difficulties to clinical application. Self‐assembling bile pigments are endogenous functional materials with excellent biocompatibility and low toxicity. Functional materials based on endogenous bile pigments provide a decent solution to this dilemma. In this review, the features and functions of self‐assembling bile pigments are discussed in detail for cancer diagnosis and treatment applications. Emphases are put on the intrinsic physicochemical characteristics of bile pigments and their applications, including drug delivery, photoacoustic imaging, photothermal therapy, and anti‐inflammation therapy. This review will promote the exploration of these areas and tremendously realize the innovative applications of self‐assembling biliverdin /bilirubin nanomaterials toward cancer diagnosis and therapy.

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Polymer-Based Nanomaterials for Noninvasive Cancer Photothermal Therapy

Cited by 60 publications

References 143 publications

Enhanced Photothermal Performance by Carbon Dot-Chelated Polydopamine Nanoparticles

Enhanced Photothermal Performance by Carbon Dot-Chelated Polydopamine Nanoparticles

Porphyrin NanoMetal-Organic Frameworks as Cancer Theranostic Agents

Self‐assembling bile pigments for cancer diagnosis and therapy

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