Implantable biomedical devices (IMDs) play essential roles in healthcare. Subject to the limited battery life, IMDs cannot achieve long-term in situ monitoring, diagnosis, and treatment. The proposal and rapid development of triboelectric nanogenerators free IMDs from the shackles of batteries and spawn a self-powered healthcare system. This review aims to overview the development of IMDs based on triboelectric nanogenerators, divided into self-powered biosensors, in vivo energy harvesting devices, and direct electrical stimulation therapy devices. Meanwhile, future challenges and opportunities are discussed according to the development requirements of current-level self-powered IMDs to enhance output performance, develop advanced triboelectric nanogenerators with multifunctional materials, and self-driven close-looped diagnosis and treatment systems.

The reliable function in vivo of self‐powered implantable bioelectric devices (iBEDs) requires biocompatible, seamless, effective interactions with biological tissues. Herein, an implantable tissue‐adhesive piezoelectric soft sensor (TPSS), in which the piezoelectric sensor converts biomechanical signals into electrical signals, and the adhesive hydrogel (AH) strengthens this conversion by seamlessly adhering the sensor on the wet and curvilinear surface, is proposed. The optimized AH exhibits strong adhesion to various organic or inorganic surfaces, including six commonly used engineering materials and three biological tissues. As a pressure sensor, TPSS proves good in vitro electrical performance with a high output of 8.3 V, long‐term stability of over 6000 cycles, and high energy power density of 186.9 µW m−2. In a large animal experiment, TPSS seamlessly adheres to the right‐side internal carotid artery of a Yorkshire pig to monitor blood pressure during a surgical operation. Compared to commercial sensors that work by inserting into tissues, TPSS does not cause any damage and can be peeled off after service. The integration of adhesive hydrogel and self‐powered pressure sensors enables biocompatible, seamless, and more efficient interactions between the biological system and iBEDs, which also contributes to next‐generation implantable bioelectronics with features of battery‐free, intelligent, and accurate.

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