Three-component cascade reactions of (E)-3-arylidene-1-methyl-pyrrolidine-2,5-diones, L-valine and various isatin derivatives are described. A series of 17 spiropyrrolidine derivatives with wide structural complexity and diversity have been thus obtained in moderate to excellent yields under mild reaction conditions. The structure and stereochemistry of these N-heterocyclic cycloadducts has been established by spectroscopic techniques and unambiguously confirmed by a single-crystal X-ray diffraction analysis performed on one derivative. UV-visible spectra have been recorded for all new compounds. Furthermore, the synthesized N-heterocyclic compounds have been screened for their in vitro antibacterial and antifungal activities. Several derivatives exhibited moderate to good activities, comparable to those of the known standard drugs Amphotericin B and Tetracycline. Structural activity relationships (SARs) and molecular docking of the most promising derivatives into the binding sites of glucosamine 6-phosphate synthase (GlcN6P) and methionyl-trna-synthetase (1PFV) were also established. Furthermore, pharmacokinetic studies indicate that the heterocycles exhibit acceptable predictive ADMET (absorption, distribution, metabolism, excretion, and toxicity) properties and good drug ability.

In this study, the (5,10,15,20-tetrakis[(4-methoxyphenyl)]porphyrinato)cadmium(ii) complex ([Cd(TMPP)]) was successfully used as a modifier in a carbon paste electrode (CPE) and exploited for bisphenol A (BPA) detection.

No abstract

In this work we report the synthesis of the cadmium(II)-meso-tetra(para-chlorophenyl)porphyrin with the morpholine O-donor axial ligand with formula [Cd(TClPP)(morph)] (I). This coordination compound adopts a distorted five-coordinate square pyramidal geometry indicated by a major doming, a moderate ruffling and saddle distortions of the porphyrinato core. The supramolecular architecture is dominated by intermolecular N−H•••Cl and C−H•••Cl interactions formed between the morpholine and the chlorine atom of the adjacent meso-phenylporphyrin of complex (I). Hirshfeld surface analysis was carried out to understand the nature of intermolecular contacts, where the fingerprint plot provides the information about the percentage contribution. UV-visible spectroscopy study highlighted the red-shift of the absorption bands after the insertion of Cd(II) metal ion into TClPP moiety and after coordination of the morpholine axial ligand. Fluorescence emission spectroscopy study showed a remarkable blue-shift effect of the Q bands followed by a dramatical diminution of the fluorescence intensity, quantum yield (φ f) and lifetime (τ f) as consequence of the high quenching effect of the cadmium heavy metal and the distortion of the porphyrin core, which promotes the loss of the "motion energy" by other non-radiative energy dissipation processes than light emission. An increase of the singlet oxygen quantum yield ( ) is also observed due to the heavy atom effect of cadmium(II) cation. The cyclic voltammetry investigation of the free base H 2 TClPP, the starting material [Cd(TClPP)] and the Cd(II)-morpholine porphyrin species (I) is also reported.

International audienceThe present work is concerned with the oxo vanadium(IV) complex of 2,3,7,8,12,13,17,18-octachloro-5,10,15,20-tetrakis(4-tolylporphyrin) with formula [V(Cl8TTP)O] (I), which was prepared by reacting the (oxo)[5,10,15,20-tetrakis(4-tolylporphyrinato)]vanadium(IV) complex ([V(TTP)O]), under aerobic atmosphere, with a large excess of thionyl chloride (SOCl2). The title compound was characterized by UV–visible spectroscopy, cyclic voltammetry and X-ray crystal structure. The electron-withdrawing chlorine substituents at the pyrrole carbons in the vanadyl-Cl8TTP derivative produce remarkable redshifts of the Soret and Q absorption bands and an important anodic shift of the porphyrin ring oxidation and reduction potentials. This is an indication that the porphyrin core of complex (I) is severely nonplanar in solution. The molecular structure of our vanadyl derivative shows a very high saddle distortion and an important ruffled deformation of the porphyrin macrocycle. The crystal structure of (I) is made by one-dimensional chains parallel to the c axis where channels are located between these chains. © 2017 Elsevier B.V

In this work, a new cadmium(II) complex namely the (1,4-diazabicyclo[2.2.2]octane)(mesotetrakis(4-tert-methoxyphenyl)porphyrinato)cadmium(II) with the formula [Cd(TMPP)(DABCO)] (I) (DABCO = 1,4-diazabicyclo[2.2.2]octane) was successfully synthetized. The structure of (I) have been characterized by FT-IR, 1 HNMR, UV-visible, fluorescence spectroscopies and single crystal Xray diffraction technique. DFT calculations has been made for the structural, 1 H NMR spectroscopy and IR spectra analysis. The adsorption of methylene blue (MB) dye was studied to examine the efficiently of the [Cd(TMPP)(DABCO)] for removing the cationic dyes from aqueous solution. The Langmuir adsorption capacity (Q 0 max ) at 290 K and pH 7.0 was found to be 69.24 mg.g -1 . The adsorption mechanism which involved π-π interaction between the MB dye molecule and the porphyrin ring of (I) is well described by the pseudo second-order and Elovich models.

No abstract

No abstract